The Relationship Between Fetal Membrane Thickness and Fetal Chromosomal Aneuploidies
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Correlation Between Fetal Membrane Thickness and Chromosomal Abnormalities
研究概览
简要总结
This observational study aims to recruit pregnant women between 18 to 24 weeks of gestation to investigate the relationship between amniotic membrane thickness and fetal chromosomal abnormalities. The primary objectives are to establish whether a correlation exists between the measured thickness of the amniotic membrane and the presence of chromosomal abnormalities in the fetus, and to determine a cutoff value for amniotic membrane thickness that could indicate an increased risk of such abnormalities. Additionally, the study seeks to assess whether the inclusion of amniotic membrane thickness as a biomarker can enhance the detection rate of non-invasive prenatal testing (NIPT) and nuchal translucency (NT) for chromosomal abnormalities.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Singleton pregnant women between 18-24 weeks of gestation.
- •Participants with high-risk indications for prenatal fetal chromosomal abnormalities, including:
- •Nuchal translucency (NT) ≥ 3 mm.
- •High-risk results from non-invasive prenatal testing (NIPT) using cell-free fetal DNA from peripheral maternal blood.
- •Ultrasound-detected fetal abnormalities.
- •Other indicators include adverse birth histories, parental chromosomal abnormalities, familial diseases, and a history of thyroid cancer post-surgery.
- •Gestational age and estimated due date were confirmed by the first day of the last menstrual period and adjusted using fetal crown-rump length measured during the first-trimester ultrasound scan.
- •Participants who provided written informed consent for amniocentesis.
排除标准
- •Women with multiple pregnancies or higher-order births.
- •Previous chorionic villus sampling or amniocentesis in the current pregnancy.
- •Gestational age at the time of amniocentesis greater than 25 weeks or less than 18 weeks.
- •Presence of amniotic band syndrome.
- •The presence of uterine anomalies or conditions may impact ultrasound measurements' reliability.
- •Any medical condition or obstetric complication that, in the opinion of the investigators, might pose a risk to the participant or interfere with the study outcomes.
结局指标
主要结局
Correlation Between Fetal Membrane Thickness and Chromosomal Abnormalities
时间窗: March, 2024
The difference in mean fetal membrane thickness between the normal and abnormal chromosomal groups, and the establishment of a threshold value for risk assessment.
次要结局
未报告次要终点