Cerebral and Spinal Protection of Xenon Post-conditioning in Patients Undergoing Aortic Dissection Repair
- Registration Number
- NCT02774096
- Lead Sponsor
- Beijing Anzhen Hospital
- Brief Summary
With more and more people developing hypertension and atherosclerosis, the morbidity rate of Acute Aortic Dissection（AAD） has been increasing. Emergency surgery is the main treatment for Acute Aortic Dissection. However the secondary injury caused by reperfusion of spinal cord could lead to Catastrophic complications,such as paraplegia, hemiplegia or even death. So spinal protection is always the hot topic in clinical research.
Xenon is an ideal anesthetic gases with the following features,fast onset of action, stable hemodynamics, clean and non-toxic.The animal researches have showed the protective effects of xenon to alleviate the ischemia-reperfusion injury of the nervous system.Those clues suggest that Xenon may have the potential protection of spinal cord in patients undergoing aortic dissection repair.In order to clarify this hypothesis, the investigators designed this randomized, controlled clinic trial to evaluate the protection of Xenon against spinal cord ischemia-reperfusion injury and the potential mechanisms
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 120
- Patients doing selective operation of Bentall and Sun's or partial aortic arch replacement
- Patients doing selective operation of the full chest and abdominal aorta replacement
- Emergency patient
- Patients with severe mental and neurological dysfunction
- Patients with severe hearing and visual impairment
- Illiteracy or patients can't cooperate with doing the cognitive function score
- Patients with severe cardiac insufficiency
- critically ill or dying patients
- Patients refuse to sign the informed consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Xenon Post-conditioning xenon undergo ascending aorta Dissection Repair and thoracoabdominal aortic Dissection Repair
- Primary Outcome Measures
Name Time Method CSF S100β the 3rd day after the surgery CSF neuron specific enolase, the 3rd day after the surgery days in hospital 15 days after leaving hospital plasma myelin basic protein(MBP) immediately after anesthesia induction ASIA's score the 3rd day after the surgery CSF IL-10 the 3rd day after surgery plasma S100β the 7th day after the surgery mini mental state examination 18h before the surgery Cerebrospinal fluid(CSF) S100β immediately after anesthesia induction CSF IL-2 the 3rd day after surgery height 18h before the surgery duration of cardiopulmonary bypass (CPB) 1h after the surgery the lowest nasopharyngeal temperature 1h after the surgery duration of extubation from the end of the surgery 3 days after the surgery pulmonary infection 15 days after the surgery plasma neuron specific enolase, the 7th day after the surgery plasma glial fibrillary acidic protein (GFAP) immediately after anesthesia induction somatosensory evoked potential(SEP) immediately after anesthesia induction males 18h before the surgery History of Hypertension 18h before the surgery duration of Aortic cross-clamping 1h after the surgery duration of recovering of consciousness from the end of the surgery 3 days after the surgery duration in the ICU 15 days after the surgery CSF IL-6 the 3rd day after surgery plasma GFAP the 7th day after the surgery NIHSS's score the 3rd day after the surgery ASIA impairment scale（ASIA's score ） 18h before the surgery History of Diabetes Mellitus 18h before the surgery New York Heart Association Heart function score 18h before the surgery duration of stopping the circulation 1h after the surgery the lowest rectal temperature 1h after the surgery duration of surgery 1h after the surgery age 18h before the surgery weight 18h before the surgery History of Smoking 18h before the surgery duration of low flow in CPB 1h after the surgery CSF GFAP the 3rd day after the surgery MEP the 4th hour after back to ICU Mini mental state ex amination the 7th day after the surgery CSF TNF-α the 3rd day after the surgery plasma MBP the 7th day after the surgery CSF neuron specific enolase(NSE), immediately after anesthesia induction CSF MBP the 3rd day after the surgery CSF Tumor Necrosis Factor-α(TNF-α) immediately after anesthesia induction CSF interleukin-10 (IL-10) immediately after anesthesia induction SEP the 4th hour after back to ICU
- Secondary Outcome Measures
Name Time Method