Glu298Asp Polymorphism and Blood Pressure
Not Applicable
Completed
- Conditions
- Hypertension
- Interventions
- Dietary Supplement: Bread
- Registration Number
- NCT02037308
- Lead Sponsor
- University of Reading
- Brief Summary
The Glu298Asp polymorphism has been linked to increased risk of cardiovascular events, proposed to be due to reduced nitric oxide production by eNOS reported in some but not all studies. We hypothesise that beetroot-enriched bread interacts with the Glu298Asp polymorphism of the eNOS gene to lower blood pressure and increase plasma nitrate/nitrite, particularly in carriers of the T allele, which have been associated with lower eNOS activity and increased risk of hypertension.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 14
Inclusion Criteria
- Male
- A signed consent form
- Age 18-64 years
- Body mass index - 18.5-30 kg/m2
- Non-smoking, healthy individuals
- Normal blood pressure at screening (< 150/90)
Exclusion Criteria
- Subjects with anaemia
- Sufferers of chronic illnesses
- Individuals with food allergies
- People with diabetes
- People with coeliac disease
- Women
- Vegetarians
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Control white bread Bread - Beetroot bread Bread -
- Primary Outcome Measures
Name Time Method Postprandial blood pressure 30 minute intervals for a period of 6 hours
- Secondary Outcome Measures
Name Time Method Postprandial plasma NOx 30 minute intervals for a total period of 6 hours
Trial Locations
- Locations (1)
Food and Nutritional Sciences, University of Reading
🇬🇧Reading, Berkshire, United Kingdom