NCT00143026已完成4 期

Study to Compare the Effect of Treatment With Carbidopa/Levodopa/Entacapone on the Quality of Life of Patients With Parkinson's Disease.

Novartis22 个研究点分布在 4 个国家目标入组 184 人开始时间: 2005年7月1日最近更新: 2017年3月29日

研究概览

简要总结

This study examines the effect of treatment of levodopa/entacapone on quality of life, as measured by the Parkinson's Disease-Questionnaire 8 (PDQ-8), in Parkinson's disease patients with no or minimal, non-disabling motor fluctuations.

详细描述

This study examines the effect of treatment of levodopa/entacapone on quality of life, as measured by the Parkinson's Disease-Questionnaire 8 (PDQ-8), in Parkinson's disease patients with no or minimal, non-disabling motor fluctuations. Treatment with carbidopa/levodopa/entacapone will be compared with treatment with standard formulation levodopa/carbidopa.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Treatment
盲法: Double

入排标准

年龄范围: 30 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Clinical diagnosis of idiopathic Parkinson's disease exhibiting at least 2 or 3 symptoms
•Motor functions must be regarded as non-disabling by the patient

排除标准

•History, signs or symptoms suggesting the diagnosis of atypical or secondary parkinsonism
•History of dyskinesia
•Previous or current use of entacapone or tolcapone
•Unstable Parkinson's disease patients requiring/receiving regimens of levodopa
•Subjects taking levodopa/DDCI controlled release or extended release formulations

结局指标

主要结局

Quality of life assessment

次要结局

Change from baseline in proportion of patients experiencing wearing-off
Symptom control change from baseline
Change from baseline in number of wearing-off symptoms

研究者

发起方

Novartis

申办方类型

Industry

责任方

Sponsor

研究点 (22)

Loading locations...

相似试验

已完成

不适用

Evaluation of the effectiveness of ND yag laser on small vascular lesions on lower limb with different energy and pulse duratio

IRCT20211203053262N1Tehran University of Medical Sciences37

尚未招募

3 期

The effect of thecarotherapy on the range of motion in patients with frozen shoulder

IRCT20230523058272N1Yazd University of Medical Sciences30

尚未招募

Unknown

Ayurvedic management of Facial paralysis

CTRI/2023/03/050987Dr BRKR Govt Ayurvedic Medical College

招募中

3 期

Comparison of the effect of enoxaparin and UFH in pregnant patients with metallic heart valve at first trimester of pregnancyPregnancy Outcome in Women with Mechanical Prosthetic Heart Valves.

IRCT20171030037093N28Esfahan University of Medical Sciences34

招募中

3 期

Therapeutic effect of 4% Dimethicone lotion with 4% Eucalyptus sp essential oil on reducing head lice infection.

IRCT20211211053349N2Kerman University of Medical Sciences192