Elucidation of Lithium Working Mechanism in Bipolar Disorder by means of Multi Modal Brain Imaging (LiBiDi) - LiBiDi

Forschungszentrum Jülich GmbH0 个研究点开始时间: 2012年7月18日最近更新: 2013年1月28日

适应症

试验速览

暂无简介。

•For all volunteers:
•blood examinations (normal level)
•thyroidal parameters (normal level)
•ECG (normal level)
•negative drug screening in urine (Benzodiazepine, Opiate, Amphetamine, Cannabis)
•no nephrological or thyroidal diseases in the medical history
•no metal in the human body
•no retainer
•Age between 18 and 60 years
•body weight > 50 kg
•pregnancy test negative
•For bipolar patients with Lithium rehabilitation:
•Diagnosis bipolar disorder type 1 referred to DSM-IVR criteria
•euthymic condition
•monotherapy with Lithium
•Lithium therapy at least for 12 months (familiar preparation, no change to another preparation)
•For bipolar patients - Lithium naive:
•Diagnosis bipolar disorder type 1 referred to DSM-IVR criteria
•euthymic condition
•no Lithium medication in the past
•no other medication for the mood treatment
•For healthy volunteers:
•no first degree relatives with psychiatric diseases in the past
•no psychiatric or neurological diseases in the past
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 80
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•- Volunteers and patients, who are not in the suitable condition for the informed consent
•- pregnancy
•- volunteers and patients before they have reached the majority age
•- persons with an exposure dose to 20 mSv during the last year
•- persons with an exposure dose to 400 mSv during the whole life
•- bipolar patients with psychiatric comorbidity like dependence, personality disorder or psychotic symptoms
•- persons, who were in a static magnetic field of 9,4T longer than 24 hours during the last year
•magnetic metal implants, contraceptive coil, tattoos

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