ACTRN12612000289819已完成3 期
Does Oral Supplementation with Taurine for Patients with Cirrhosis and Muscle Cramps Reduce the Severity and Frequency of Muscle Cramps?
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 49
研究概览
简要总结
Oral supplementation with 2 g taurine/d is safe and results in a clinically significant reduction in the frequency, duration, and intensity of muscle cramps in patients with chronic liver disease. Taurine should be considered as a safe and effective intervention in the management of muscle cramps in individuals with chronic liver disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 70 Years（—）
- 性别
- All
入选标准
- •Patients who present to liver clinic with hepatic cirrhosis and who experience muscle cramps more than three times/week
- •Abstinent from alcohol and intravenous drug use for 3 months prior to entry into study
- •If on methadone must be on methadone for 12 months or longer and must be dose stable for 3 months prior to entry into study
排除标准
- •Muscle cramps less than two occasions/week
- •Abnormal levels potassium, magnesium and phosphate
- •Unstable diabetes or a blood sugar level > 15mMol at time of assessment for inclusion in the study
- •Known peripheral neuropathy
- •Known thyroid disease
- •Pulmonary hypertension
- •Known cardiac disease
- •Current or recent (within 3 months of assessment)intravenous drug use
- •Methadone use for less than 12 months
- •Current use of taurine enriched energy drinks
研究者
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