Effect of Dexmedetomidine Versus Dexamethasone as Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block on Postoperative Analgesia in Myasthenic Patients Undergoing Thoracoscopic Thymectomy
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 主要终点
- the duration between the surgery end and the 1st rescue analgesia the patient requested.
研究概览
简要总结
This current comparative study involved 54 patients undergoing thoracoscopic thymectomy who were distributed randomly into three equal groups to receive ultrasound (US)-guided ESPB using 20 ml bupivacaine 0.25% (group B) , 20 ml bupivacaine 0.25% with 8 mg dexamethasone (group BS), 20 ml bupivacaine 0.25% with dexmedetomidine 1mcg/kg (group BM). The time till the first postoperative rescue analgesic requested was the primary outcome. The secondary outcomes included the postoperative pain scores and analgesic consumption.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •myasthenic patients
- •American Society of Anesthesiologists (ASA) physical grade of 2-3)
- •who underwent video assisted thoracoscopic thymectomy
排除标准
- •Refused participation in the study,
- •known allergy for this study drugs ,
- •Contraindication to the ESPB as infection at block site & marked chest cage deformity,
- •significant bleeding disorders ,
- •patients with significant renal or liver dysfunction,
- •heart block ,
- •poor ventilatory function,
- •severe chronic obstructive pulmonary disease,
- •morbid obesity,
- •mental disability, or communication difficulties that hindered effective pain assessment,
- •Individuals who was converted to open thoracotomy or those re-explorated for surgical related issues.
研究组 & 干预措施
(group B)
ultrasound (US)-guided ESPB using 20 ml bupivacaine 0.25%
干预措施: Erector Spinae Plane Block (Procedure)
Group BS
20 ml bupivacaine 0.25% with 8 mg dexamethasone
干预措施: Erector Spinae Plane Block (Procedure)
Group BM
20 ml bupivacaine 0.25% with dexmedetomidine 1mcg/kg
干预措施: Erector Spinae Plane Block (Procedure)
结局指标
主要结局
the duration between the surgery end and the 1st rescue analgesia the patient requested.
时间窗: 24 hours postoperatively
次要结局
- .Total ketorolac consumption(24 hours postoperatively)
- . Number of patients needed rescue tramadol(24 hours postoperatively)
研究者
RAMY AHMED
Assisstant professor of anesthesia,intensive care and pain management
Ain Shams University