The effect of dexmedetomedine and melatonin on delirium

Phase 3

Recruiting

• Conditions: Patients candidate for coronary artery bypass graft surgery.; Unspecified complication of cardiac and vascular prosthetic device, implant and graft; T82.9

• Registration Number: IRCT20180909040979N7
• Lead Sponsor: Ahvaz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 30 May 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Candidate for coronary artery bypass graft surgery with cardiopulmonary pump
No allergy to melatonin and dexmedetomidine
Elective surgery
Age 40 to 75 years

Exclusion Criteria

Conscious dissatisfaction
Emergency surgery
Chronic use of melatonin or hypnotic drugs
History of liver or kidney disease or chronic lung disease
History of neurological or psychological diseases
Ejection Fraction < 30%

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Delirium incidence. Timepoint: First day and second day after extubation. Method of measurement: Based on Confusion Assessment Method for the ICU.;Severity of delirium. Timepoint: First day and second day after extubation. Method of measurement: Based on Confusion Assessment Method for the ICU.

Secondary Outcome Measures

Name	Time	Method
Mechanical ventilation duration. Timepoint: 6,8,10,12 ,24 hours after surgery. Method of measurement: Hour.;Duration of ICU staying. Timepoint: 2,3,4 days after surgery. Method of measurement: Day.