Pharmacokinetic of methadone in critically ill patients
Not Applicable
- Conditions
- critically ill patients in ICU.
- Registration Number
- IRCT2013012610817N3
- Lead Sponsor
- Tehran University of Medical Siences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Inclusion criterion: critically ill patients in ICU, who require pain management with opioids.
Exclusion criteria: hypersensitivity to methadone or any component of the formulation; patients older than 65 years old; patients with renal failure( Scr > 2mg/dl ,Urine Output <0.5cc/kg/hour) 4. ); patients with hepatic failure(hepatic enzymes more than 3 times normal); patients with Platelet less than 100000; mean arterial pressure less than 65 or who require inotrope or vasopressor and patient who suffer ALI (PaO2 /FIO2<300).
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Plasma methadone concentration. Timepoint: 1st and 6th day of the study. Method of measurement: chromatography.;Methadone plasma concentration. Timepoint: on 1st and 6th day, 1,4, 8 and 12 hours after the last dose. Method of measurement: HPLC.
- Secondary Outcome Measures
Name Time Method