Effects of Marine n-3 Fatty Acid Infusion on Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 11
- 试验地点
- 2
- 主要终点
- insulin sensitivity
研究概览
简要总结
The purpose of this experimental study is to investigate whether an acute lipid infusion added marine n-3 fatty acids produces effects on insulin sensitivity in subjects with type 2 diabetes, when compared with an acute lipid infusion without marine n-3 fatty acids. Furthermore other effects on intermediary metabolism are tested for.
详细描述
Evidence indicates that n-3 fatty acids exert several beneficial effects. However, the effects of marine n-3 fatty acids on intermediary metabolism have not been completely elucidated. In a previous study of a high intake of marine n-3 fatty acids during 9 wk we demonstrated reduced insulin sensitivity and altered proportion of carbohydrate vs. fat oxidation in subjects with type 2 diabetes. These results question the use of high doses of n-3 supplements in type 2 diabetes. It is not known to what extent such effects in type 2 diabetes can be reproduced by intravenous administration of n-3 fatty acids and/or whether short term intravenous administration has other effects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 30 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 2 diabetes defined by clinical criteria and by absence of antibodies to glutamic acid decarboxylase.
- •HbA1c 5,5 - 8,5 %
- •Blood pressure ≤ 170 mm Hg systolic and/or ≤ 105 mm Hg diastolic
排除标准
- •insulin treatment
- •hypertriglyceridemia (> 2,1 mmol/l TG)
- •proliferative retinopathy, renal insufficiency (Se-Creatinine > 150 μmol/l)
- •alcoholism, congestive heart failure or other serious diseases affecting the possibility of the subject to participate
- •supplement with fish oil or marine n-3 fatty acids during the last 6 months before baseline
- •Dicumarol treatment
- •allergy to soya, fish or egg
- •pregnancy or lactation
结局指标
主要结局
insulin sensitivity
时间窗: 4 hours
次要结局
- n-3 fatty acid distribution(4 hours)
- insulin secretion(4 hours)
- energy metabolism(4 hours)
- oxidative stress(4 hours)