Prospective Assessment of Peripheral-vestibular Function After Skull Base Surgery

Not Applicable

Completed

• Conditions: Vestibular
• Interventions: Other: head-impulse testing

• Registration Number: NCT02773277
• Lead Sponsor: University of Zurich

Brief Summary

Due to its localization in the cerebello-pontine angle, the vestibulo-cochlear nerve is at risk to damage during surgery performed nearby. In most cases, peripheral-cochleovestibular hypofunction recovers over the following weeks as the mechanism of damage is rather demyelination than axonal damage. The rate, intensity and extent of recovery of such perioperative peripheral-vestibular damage is not known.

Detailed Description

Due to its localization in the cerebello-pontine angle, the vestibulo-cochlear nerve is at risk to damage during surgery performed nearby, e.g. when removing an epidermoid cyst, treating a neuro-vascular conflict of the trigeminal nerve or resecting a petroclival meningeoma. Intense vertigo and dizziness accompanied by spontaneous nystagmus following Alexander's law, nausea and gait imbalance may be noted in these patients along with cochlear hypofunction (hearing loss). In most cases, peripheral-cochleovestibular hypofunction recovers over the following weeks as the mechanism of damage is rather demyelination than axonal damage. The rate, intensity and extent of recovery of such perioperative peripheral-vestibular damage is not known. Besides peripheral-vestibular hypofunction, transient cerebellar hypofunction may arise, presenting with similar complaints (vertigo, nausea, gait imbalance), however, distinct subtle ocular motor findings.

The aim of this study is to characterize the frequency and pattern of iatrogenic peripheral-vestibular and cochlear hypofunction and to follow-up on the speed and extent of recovery. The investigators hypothesize that peripheral-vestibular and cochlear damage may be observed in a significant fraction of neurosurgical treatments in the posterior fossa including the cerebello-pontine angle. While initially deficits may be major, recovery is expected to be substantial or even complete due to peripheral restoration. As an important differential diagnosis, the investigators will evaluate also for potential (transient) cerebellar loss of function.

In order to quantify peripheral-vestibular function the investigators will use a CE-certified videooculography device to record responses to the head-impulse test before and in the days following elective skull base surgery. the video-head impulse test (vHIT) allows a quantitative video-based assessment of the functional integrity of all semicircular canals (MacDougall et al. 2013). By use of a high-speed video-camera mounted on goggles this test quantifies the vestibulo-ocular reflex (VOR), which is the fastest human reflex and allows the recognition and visual fixation of objects while head turns or ambulation. This test is used on a routine basis in our clinic and includes brief and fast, but small amplitude head turns (10-15° excursion) in the planes of the different semi-circular canals (SCCs). The SCCs are tested in three pairs in the horizontal, RALP (right anterior, left posterior) and LARP (left anterior, right posterior) plane (Weber et al. 2008). During testing the participant is asked to fixate a visual target straight ahead. Duration of this test: about 15 minutes.

Study Timeline

• Study First Submitted: 2016-05-09
• Study First Submitted QC: 2016-05-13
• Study First Posted: 2016-05-16
• Study Start: 2016-06-01
• Primary Completion: 2019-05-31
• Study Completion: 2019-05-31
• Status Verified: 2019-12
• Last Update Submitted: 2020-01-06
• Last Update Posted: 2020-01-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

1. aged 18 years or older
2. informed consent
3. absence of exclusion criteria

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Exclusion Criteria

1. peripheral-vestibular deficit before surgery
2. disturbed consciousness
3. diagnosis of vestibular schwannoma
4. other neurological or systemic disorder which can cause dementia or cognitive dysfunction
5. known neck pain or status post neck trauma

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Single intervention arm	head-impulse testing	All patients will be assigned the intervention arm and will receive head-impulse testing before and in the days after skull base surgery.

Primary Outcome Measures

Name	Time	Method
gain of the angular vestibulo-ocular reflex	comparison before surgery and up to 30 days post surgery	in all patients the mean gain for each semicircular canal will be determined
Cumulative saccade amplitudes per trial [°/trial] of the angular vestibulo-ocular reflex	comparison before surgery and up to 30 days post surgery	in all patients the cumulative saccade amplitudes per trial for each semicircular canal will be determined

Secondary Outcome Measures

Name	Time	Method
clinical testing for skew deviation by use of the alternating cover test	comparison before surgery and up to 30 days post surgery	besides the vHIT, patients will be examined clinically, including testing for central-type acute vestibular syndrome.
clinical testing of the horizontal head-impulse test	comparison before surgery and up to 30 days post surgery	besides the vHIT, patients will be examined clinically, including testing for central-type acute vestibular syndrome.
clinical testing for gaze-evoked nystagmus	comparison before surgery and up to 30 days post surgery	besides the vHIT, patients will be examined clinically, including testing for central-type acute vestibular syndrome.