Effects of Calcium and Phytate on Zinc Absorption
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 17
- Locations
- 2
- Primary Endpoint
- Zinc Absorption
Study Overview
Brief Summary
This study is determine the effects of dietary calcium and phytate on zinc absorption.
Detailed Description
Zinc absorption is tested from 2 days of consuming each of four diets with zinc-65 isotope, followed by retention monitoring in a whole body scintillation counter for 4 weeks. All four 4 experimental diets are tested with each subject, in randomized order, for a total of 16 weeks.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Factorial
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 21 Years to 50 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Average weight for height
Exclusion Criteria
- •Medications other than birth control pills or hormone replacement therapy,
- •Pregnancy within last 6 months
Arms & Interventions
Overall Study
Participants consumed 4 experimental diets for 4 weeks each in randomized order
Intervention: Moderate Calcium, Low phytate Diet (Dietary Supplement)
Overall Study
Participants consumed 4 experimental diets for 4 weeks each in randomized order
Intervention: Moderate Calcium, High Phytate Diet (Dietary Supplement)
Overall Study
Participants consumed 4 experimental diets for 4 weeks each in randomized order
Intervention: High Calcium, Low Phytate Diet (Dietary Supplement)
Overall Study
Participants consumed 4 experimental diets for 4 weeks each in randomized order
Intervention: High Calcium, High Phytate Diet (Dietary Supplement)
Outcomes
Primary Outcomes
Zinc Absorption
Time Frame: 16 weeks
Retention of Zinc-65 was monitored for 28 days by whole body scintillation counting. The percentage of Zinc-65 absorbed was estimated from the y-intercept of the linear portion of a semilogarithmic retention plot of percent Zinc-65 retained versus time
Secondary Outcomes
No secondary outcomes reported