Study to compare the effect of melatonin gel in combination with artificial bone material in treating bony defects caused by gum diseases.
Not Applicable
- Conditions
- Health Condition 1: K053- Chronic periodontitis
- Registration Number
- CTRI/2023/07/055039
- Lead Sponsor
- G Laxmi Kavya
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patients with localized or generalized periodontitis of stage-II and stage-III with grade B and C as per 2017 classification
2.Two and three walled intrabony defects with radiologic vertical bone loss of >= 3mm at baseline and a PPD >=5mm when persistent after non-surgical therapy
Exclusion Criteria
1.Patients with poor oral hygiene
2.Uncontrolled systemic diseases
3.Patients under antibiotic therapy
4.Smokers, tobacco chewers
5.Pregnant and lactating women
6.Patients receiving periodontal treatment during last 6 months
7.Patients under melatonin supplement therapies
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Probing pocket depth <br/ ><br>2.Clinical attachment level <br/ ><br>3.Linear amount of bone fill <br/ ><br>4.Bone volume <br/ ><br>Salivary Biomarkers - <br/ ><br>5.RANKL and <br/ ><br>6.Osteoprotegerin in GCF <br/ ><br> <br/ ><br> <br/ ><br>Timepoint: 1.Probing pocket depth at baseline 3 months 6 months <br/ ><br>2.Clinical attachment level at baseline 3 months 6 months <br/ ><br>3.Linear amount of bone fill at baseline & 6 months <br/ ><br>4.Bone volume at baseline & 6 months <br/ ><br>Salivary Biomarkers - <br/ ><br>5.RANKL in GCF at baseline & 6 months <br/ ><br>6.Osteoprotegerin in GCF at baseline & 6 months <br/ ><br> <br/ ><br> <br/ ><br> <br/ ><br> <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1.Plaque index <br/ ><br>2.Sulcus bleeding indexTimepoint: 1.Plaque index at baseline,3 months ,6 months <br/ ><br>2.Sulcus bleeding index at baseline,3 months, 6 months