ITMCTR2022000023招募中早期 1 期
To explore the molecular mechanism of chronic urticaria with syndrome of dampness and heat in the intestines and stomach from the perspective of gastrointestinal microecological imbalance
Guang'anmen Hospital, China Academy of Chinese Medicine Sciences0 个研究点开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 早期 1 期
- 状态
- 招募中
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational study
入排标准
- 年龄范围
- 18 至 50（—）
- 性别
- All
入选标准
- •Inclusion criteria for patients with chronic urticaria: 1) Age 18-50; 2) Meet the western diagnostic criteria of chronic urticaria; 3) Meet the diagnostic criteria of TCM for chronic urticaria; 4) TCM syndrome differentiation conforms to chronic urticaria gastrointestinal dampness and heat syndrome or not syndrome of dampness and heat in the intestines and stomach (wind-heat syndrome, wind-cold syndrome, toxic heat and excessive heat syndrome or qi and blood deficiency syndrome); 5) Sign informed consent.
排除标准
- •Exclusion criteria for patients with chronic urticaria: 1) with acute urticaria, drug sex urticaria, induced urticaria (cold sex urticaria, hot sex urticaria, solar sex urticaria, delay pressure sex urticaria, anti-vibration effect sex urticaria, cholinergic urticaria, sex urticaria, etc.), urticaria, vasculitis and other associated with urticaria appearance of the skin disease; 2) Had received hormone, immunosuppressant or biological agent treatment in the last 3 months, or received relevant Traditional Chinese medicine treatment one week before enrollment; 3) Women who are pregnant, trying to become pregnant or breastfeeding; 4) With a history of severe respiratory, digestive, circulatory, urinary, hematological, endocrine or nervous system diseases. 5) There were the following factors affecting fecal collection: (1) gastrointestinal surgery (e.g., cholecystectomy and appendectomy) within 5 years, or other operations within 6 months; (2) a history of autoimmune disease, such as inflammatory bowel disease (IBD), including ulcerative colitis, Crohn's disease, or colitis of unknown etiology; (3) Previous history of irritable bowel syndrome (IBS), gastric cancer and pregastric cancer; (4) Used antibiotics within 3 months; (5) drugs containing bismuth basic salicylate and other similar bismuth basic salicylate have been used in the past 1 week; (6) Have eaten probiotic-containing food or drugs, such as yogurt and cheese, in the past 2 weeks; (7) Have bad habits such as alcoholism, men drink 5 times a week or more, women drink 4 times a week or more, the average amount of alcohol per time is more than 2 liang liquor or 5 bottles of beer. 6) Patients who refuse to sign informed consent.
研究者
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