The Zambia, South Africa, Tuberculosis and Acquired Immune Deficiency Syndrome-reduction Trial

Not Applicable

Completed

• Conditions: Tuberculosis; Infections and Infestations

• Registration Number: ISRCTN36729271
• Lead Sponsor: Consortium to Respond Effectively to the AIDS-Tuberculosis Epidemic (CREATE) (USA)

Brief Summary

2013 Results article in http://www.ncbi.nlm.nih.gov/pubmed/23915882 results 2021 Other publications in https://pubmed.ncbi.nlm.nih.gov/34907038/ secondary analysis (added 16/12/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-05-05
• Study Completion: 2010-07-01
• Last Update Posted: 27 December 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1500000

Inclusion Criteria

Population served by tuberculosis diagnostic centre in each of 24 communities

Exclusion Criteria

Individuals who do not consent to trial procedures

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome will be the prevalence of culture-positive tuberculosis among a randomly selected population of adults in each arm of the trial, measured after 3 years of the interventions

Secondary Outcome Measures

Name	Time	Method
Secondary outcomes measured at the community level include:<br>1. Cumulative incidence of tuberculosis infection in school children<br>2. Indicators of tuberculosis and HIV programme performance<br><br>At the household level, they include:<br>1. Cumulative incidence of tuberculosis<br>2. Changes in HIV incidence and stigma