Emotional and Change-related Attention in Autism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Neural responses to neutral and emotional stimuli
研究概览
简要总结
Several studies seem to indicate that emotional attention and change-related attention are impaired in ASD. The goal of this study is to identify the relationships between those two types of automatic attention in visual and auditory modalities in subjects with ASD compared to healthy controls and also, over the course of development (children, adults). In order to achieve this goal, the investigators will use complementary techniques (EEG and MRI-based techniques (fMRI, DTI)).
详细描述
Autism Spectrum Disorders (ASD) are characterized by major handicap in social interaction and in daily life adaptation. The orienting response towards potentially relevant events involves automatic attentional mechanisms that would be elicited mainly by two classes of biologically important stimulations: novel stimuli and emotional stimuli. The neural basis of emotional and change-related attention in ASD will be explored by investigating brain reactivity in both visual and auditory modalities, during tasks mixing emotional and non emotional stimuli.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 5 Years 至 45 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •No past history of central nervous system disorders
- •Written consent
- •Affiliated to the National Health Insurance
- •Do not participate to another biomedical research
- •For ASD group: Children with autism spectrum disorder (DSM-V criteria) and adults with high-functioning autism
- •For healthy subjects: No past history of difficulties in early childhood for acquisition of walk, language or reading and no psychiatric disorders
排除标准
- •Abnormal corrected vision
- •Abnormal audition
- •Not stabilized psychoactive treatment or treatment that can modify electrogenesis
- •Infectious or metabolic diseases
- •Epilepsies
- •Impossibility to participate to the whole study
- •For subjects participating to the MRI recordings: MRI counter-indications (pace-makers ...), claustrophobia or a positive pregnancy test
结局指标
主要结局
Neural responses to neutral and emotional stimuli
时间窗: 1 day
ERP (Event-related potential), fMRI and DTI
次要结局
未报告次要终点