IRCT20180515039662N1RecruitingPhase 3
Effect of N-acetylcysteine on nitric oxide, oxidative stress biomarkers, depression and stress in patients with multiple sclerosis
Conditions
Trial Snapshot
- Phase
- Phase 3
- Status
- Recruiting
- Enrollment
- 60
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 years to 60 years (—)
- Sex
- All
Inclusion Criteria
- •Patients with multiple sclerosis more than 2 years
- •EDSS = 4/5
- •Patients without current diagnosis of other inflammatory or autoimmune disease
- •The age range is between 18-60 years
- •Not taking depression or anxiety drugs
- •Score of 10-30 (mild to moderate depression) from Beck Depression questionnaire in depression subscal and 15-25 (mild to moderate anxiety) from DASS21 questionnaire
- •Tendency to participate in the study
Exclusion Criteria
- •Clinical relapses within 3 months before or during the study
- •Pregnancy and lactation
- •Cardiovascular diseases
- •Patients with blood pressure disorders
- •Liver and kidney disease
- •Bronchospasm, asthma and any respiratory failure
- •Gastric ulcer
- •Bleeding and impaired blood coagulation
- •Those who are allergic to NAC and any combination it contains,
- •Taking antioxidants or NAC over the past 60 days
- •Smoking, alcohol or drugs abuse
- •Stressful events during the study
Investigators
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