The effect of N-acetylcysteine in the treatment of multiple sclerosis

Phase 3

Recruiting

• Conditions: multiple sclerosis.; Multiple sclerosis

• Registration Number: IRCT20180515039662N1
• Lead Sponsor: Ahvaz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 16 July 2018

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients with multiple sclerosis more than 2 years
EDSS = 4/5
Patients without current diagnosis of other inflammatory or autoimmune disease
The age range is between 18-60 years
Not taking depression or anxiety drugs
Score of 10-30 (mild to moderate depression) from Beck Depression questionnaire in depression subscal and 15-25 (mild to moderate anxiety) from DASS21 questionnaire
Tendency to participate in the study

Exclusion Criteria

Clinical relapses within 3 months before or during the study
Pregnancy and lactation
Cardiovascular diseases
Patients with blood pressure disorders
Liver and kidney disease
Bronchospasm, asthma and any respiratory failure
Gastric ulcer
Bleeding and impaired blood coagulation
Those who are allergic to NAC and any combination it contains,
Taking antioxidants or NAC over the past 60 days
Smoking, alcohol or drugs abuse
Stressful events during the study

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Glutathione. Timepoint: The beginning of the study- The end of the study. Method of measurement: Spectrophotometry.;Malondialdehyde. Timepoint: The beginning of the study- The end of the study. Method of measurement: Spectrophotometry.;Total antioxidant capacity. Timepoint: The beginning of the study- The end of the study. Method of measurement: Spectrophotometry.;Nitric oxide. Timepoint: The beginning of the study- The end of the study. Method of measurement: Spectrophotometry.;Depression. Timepoint: The beginning of the study- The end of the study. Method of measurement: Beck questionnaire.;Anxiety. Timepoint: The beginning of the study- The end of the study. Method of measurement: DASS 21 questionnaire.

Secondary Outcome Measures

Name	Time	Method
Body Mass Index. Timepoint: The beginning of the study- The end of the study. Method of measurement: Body weight / hight square (kg/m2).;Dietary intake. Timepoint: The beginning of the study- The end of the study. Method of measurement: Three-day record.