Effect of Sodium Bicarbonate Buccal Infiltration on the Success of Inferior Alveolar Nerve Block in the Mandibular First Molar With Symptomatic Irreversible Pulpitis: a Prospective, Randomized Double-blind Study
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- success rate of IANB in the mandibular first molar with symptomatic irreversible pulpitis
研究概览
简要总结
The purpose of this prospective, randomized, double blind study was to evaluate the effect of a buccal infiltration of sodium bicarbonate on the anesthetic success of the inferior alveolar nerve block (IANB) in patients with mandibular first molar experiencing symptomatic
详细描述
Several studies have been done by adding Sodium Bicarbonate to local anesthesia in dentistry based on the theory that the amount of local anesthetic in the free-base un-ionized form will decrease to provide greater lipid penetration of the nerve and this could be cause of the failure of local anesthesia injected into the inflamed tissue with low PH and conflicting results were obtained. But, there are no study that evaluate effect of increasing PH in periradicular tissue on hindrance of resistance channels with supplementary infiltration injection of Sodium Bicarbonate
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •vital mandibular molar tooth
- •diagnosis of symptomatic irreversible pulpitis
排除标准
- •younger than 18 years old
- •history of significant medical conditions
- •allergies to local anesthetics or sulfites
- •pregnancy
- •taking any medications that might influence anesthetic assessment
- •active sites of pathosis in area of injection
- •inability to give informed consent
研究组 & 干预措施
sodium bicarbonate
0.7 mL of 8.4% sodium bicarbonate & 0.3 mL of 2% lidocaine with 1:100,000 epinephrine
干预措施: sodium bicarbonate (Drug)
sodium bicarbonate
0.7 mL of 8.4% sodium bicarbonate & 0.3 mL of 2% lidocaine with 1:100,000 epinephrine
干预措施: Lidocaine (Drug)
Non-sodium bicarbonate
Sterile distilled water & 0.3 mL of 2% lidocaine with 1:100,000 epinephrine
干预措施: Lidocaine (Drug)
Non-sodium bicarbonate
Sterile distilled water & 0.3 mL of 2% lidocaine with 1:100,000 epinephrine
干预措施: sterile distilled water (Drug)
结局指标
主要结局
success rate of IANB in the mandibular first molar with symptomatic irreversible pulpitis
时间窗: Baseline
次要结局
- Heft-Parker visual analog scale recording of pain(Baseline)
研究者
Masoud Saatchi
Professor of Endodontics, School of Dentistry, Isfahan University of Medical Sciences
Isfahan University of Medical Sciences