NCT02266004终止不适用
Transcranial Direct Current Stimulation for Freezing of Gait in Patients With Parkinson's Disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 9
- 试验地点
- 2
- 主要终点
- Change in Walking Speed
研究概览
简要总结
This study will evaluate the effects of transcranial direct current stimulation (tDCS) in combination with locomotor training in patients with Parkinson's disease (PD) and freezing of gait (FOG).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Parkinson's disease stages 2-3 Hoehn and Yahr.
- •Presence of Freezing of Gait
- •Stable medication regimen
- •Time to complete TUG >12 seconds
排除标准
- •medical condition that would interfere with walking and training for 30 minutes
- •unable to perform timed up and go in the off condition
- •history of seizures
- •implanted deep brain stimulator, pacemaker or any other electronic device.
- •Adults unable to consent, individuals who are not yet adults (infants, children, teenagers) pregnant women, prisoners will not be considered for participation
结局指标
主要结局
Change in Walking Speed
时间窗: baseline, 3 weeks
walking speed will be measured using sensors during a 90 second walk
次要结局
- Change in Motor Scores as Measured by Unified Parkinson's Disease Rating Scale (UPDRS)(baseline, 3 weeks)
- Change in Postural Sway(baseline, 3 weeks)
- Change in Glutamate/Gamma Aminobutyric Acid(GABA) Ratio(baseline, 3 weeks)
- Change in the Trail Making Test Time(baseline, 3 weeks)
- Change in Backward Digit Span(baseline, 3 weeks)
- Change in Stride Length(baseline, 3 weeks)
- Change in the Montreal Cognitive Assessment (MOCA)(baseline, 3 weeks)
- Change in the Freezing of Gait Questionnaire (FOG-Q)(baseline, 3 weeks)
- Change in Timed Up-and-Go (TUG) Time(baseline, 3 weeks)
- Change in Motor Threshold(baseline, 3 weeks)
- Change in the Auditory Consonant Trigrams Test (ACT)(baseline, 3 weeks)
研究者
Corneliu C Luca
Assisstant Professor of Neurology
University of Miami
研究点 (2)
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