Measure of Intracranial Pressure Variations During Migraine Attacks
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Intracranial pressure variations
研究概览
简要总结
An increase in intracranial pressure (ICP) during migraine attacks is possible and could contribute to pain initiation and maintenance. From now on, it was not possible to measure ICP in a non-invasive way. The development of a new tool allows non-invasive self-measures of ICP variations. Thus, it is possible for the first time to look for such ICP variations during migraine attacks and to conclude if this mechanism is implied in the pathophysiology of migraine.
详细描述
Womens presenting with regular menstrual migraine treated with triptans will be included in the study. Self-measure of ICP will be performed outside and during menstrual migraine attacks. The potential variations will be compared to the measures done on matched healthy women outside and during menses.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •18 to 50 non menopausal women
- •Menstrual migraine
- •Using a triptan as usual treatment to relieve attacks
- •Usual triptan efficacy although recurrence is possible
排除标准
- •Disease of the ear
- •Intracranial hypertension
- •Chronic daily headache
- •Use of topiramate or acetazolamide
- •Triptans used more than 10 days/month
- •Analgesic drug used more than 15 days/month
- •Uncontrolled high blood pressure
- •Ongoing allergic rhinitis or flu
结局指标
主要结局
Intracranial pressure variations
时间窗: during menstrual migraine attacks
Measured during menstrual migraine attacks compared to ICP in non-migraine days and in matched healthy women
次要结局
- Relationships between ICP variations and clinical parameters(during menstrual migraine attacks)
- Relationships between ICP variations and pain relief(during menstrual migraine attacks)