Rapid Analysis and Response Evaluation of Combination Anti-Neoplastic Agents in Rare Tumors (RARE CANCER) Trial: RARE 1 Nilotinib and Paclitaxel
概览
- 阶段
- 2 期
- 干预措施
- Nilotinib and Paclitaxel
- 疾病 / 适应症
- Neoplasms
- 发起方
- National Cancer Institute (NCI)
- 入组人数
- 82
- 试验地点
- 1
- 主要终点
- Objective response
- 状态
- 招募中
- 最后更新
- 5天前
概览
简要总结
Background:
People with rare cancers often have limited treatment options. The biology of rare cancers is not well understood. Researchers want to find better treatments for these cancers. They want to test 2 drugs that, taken separately, have helped people with non-rare cancers. They want to see if these drugs together can make rare cancers shrink or stop growing.
Objective:
To learn if nilotinib and paclitaxel will benefit people with rare cancers.
Eligibility:
People age 18 and older who have a rare, advanced cancer that has progressed after receiving standard treatment, or for which no effective therapy exists.
Design:
Participants will be screened with medical history and physical exam. They will have blood and urine tests. They will have a pregnancy test if needed. They will have an electrocardiogram to check their heart. They will have imaging scans to measure their tumors.
Participants will repeat the screening tests during the study.
Participants will receive nilotinib and paclitaxel. The drugs are given in 28-day cycles. Nilotinib is a capsule taken by mouth twice a day. Paclitaxel will be given intravenously by peripheral line or central line once a week for the first 3 weeks of each cycle.
Participants will keep a medicine diary. They will track when they take the study drugs and any side effects they may have.
Participants may have optional tumor biopsies.
Participants can stay on the study until their disease gets worse or they have intolerable side effects.
Participants will have a follow-up phone call about 30 days after taking the last dose of study drugs.
详细描述
Background: * Rare tumors constitute a heterogeneous group of cancers associated with limited treatment options and poor outcomes. Due to their rarity, there are few good models for these diseases to support preclinical evaluation of new anticancer agents. To address these challenges, DCTD s Patient-Derived Models Repository (PDMR) is generating patient-derived xenograft models of adult and pediatric rare cancers and has screened combinations of approved and investigational anticancer agents in these models. * Based on preclinical activity, drug combinations are being tested in patients with rare cancers in a series of connected Phase 2 clinical trials (Rapid Analysis and Response Evaluation of Combination Anti-Neoplastic Agents in Rare Tumors \[RARE CANCER\]); responses may trigger further evaluation of a treatment in that rare cancer type to further evaluate response rate and mechanism-of-action. Patients who progress will be offered another RARE CANCER trial. * The agents used in this trial are the BCR-Abl kinase inhibitor nilotinib and the anti-tubulin agent paclitaxel, which showed greater than additive activity in combination in preclinical xenograft models and subsequently demonstrated clinical efficacy (including partial responses) in patients with solid tumors on the Phase 1 trial 15-C-0086 (NCT02379416). Primary Objectives: \- To evaluate the proportion of patients with advanced rare cancers who have objective responses (OR) to treatment with nilotinib and paclitaxel Exploratory Objectives: * To evaluate the proportion of patients alive and progression free at 6 months on study agents * To identify genomic and transcriptomic determinants of response and resistance in tumor biopsy specimens * To examine genomic alterations in circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) that may be associated with response or resistance * To evaluate the pharmacodynamic effects of the combination on biomarkers of cell death and epithelial-to-mesenchymal transition in tumor tissue and CTCs Eligibility: * Study participants must have a histologically confirmed solid tumor meeting the RARECARE definition of rare tumor that has progressed on standard therapy known to prolong survival or for which no standard treatment options exist; with Mod G (6-17-24), eligibility will be limited to patients with granulosa cell ovarian cancer, clear cell ovarian cancer, anal cancer, or Ewing sarcoma. * Age \>= 18 * No major surgery, radiation, or chemotherapy within 3 weeks prior to entering the study (6 weeks for nitrosoureas and mitomycin C) or 5 half-lives of the agent, whichever is shorter; toxicity from prior treatment must have recovered to eligibility levels. * Adequate organ function; performance status ECOG 0-2 Study Design: * Nilotinib will be administered at 300 mg orally BID and paclitaxel will be administered IV at 80 mg/m\^2 on Days 1, 8, and 15 in 28-day cycles. * A single-stage design will be used with a target accrual of 30 eligible patients. If at least 4/30 patients experience an objective response (PR or CR by RECIST 1.1), the combination of nilotinib and paclitaxel will be considered promising. The accrual ceiling is 34 patients.
研究者
入排标准
入选标准
- •INCLUSION CRITERIA:
- •Patients must have histologically confirmed rare solid tumors that have progressed on standard therapy known to prolong survival or for which no standard treatment options exist. The list of eligible rare tumors can be found below\*\*. With Amendment G (v 6-17-24), eligibility will be limited to patients with adult granulosa cell ovarian cancer, clear cell ovarian cancer, anal cancer, or Ewing sarcoma.Patients must have measurable and evaluable disease.
- •Age \>= 18 years.
- •ECOG performance status \<=
- •Patients must have normal organ and marrow function as defined below:
- •Absolute neutrophil count \>=1,500/mcL
- •Platelets \>=100,000/mcL
- •Total bilirubin \<=1.5 X institutional ULN
- •AST(SGOT)/ALT(SGPT) \<=3 X institutional upper limit of normal; \<= 5.0 x ULN in patients with liver metastases
- •creatinine \<=1.5 X institutional ULN OR
排除标准
- •QTcF interval of \>=450 msec at study entry; congenital long QT syndrome
- •Sensory/motor neuropathy \>= Grade 2
- •Patients who are receiving any other investigational agents.
- •Patients with known primary central nervous system (CNS) malignancy or symptomatic CNS metastases are excluded, with the following exceptions:
- •Patients with asymptomatic untreated CNS disease may be enrolled, provided all of the following criteria are met:
- •Evaluable or measurable disease outside the CNS
- •No metastases to brain stem, midbrain, pons, medulla, or cerebellum
- •No history of intracranial hemorrhage or spinal cord hemorrhage
- •No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted.
- •No neurosurgical resection or brain biopsy within 28 days prior to Cycle 1, Day 1
研究组 & 干预措施
1
Nilotinib will be administered at 300 mg orally BID; Paclitaxel will be administered IV at 80 mg/m2 on Days 1, 8, and 15 in 28-day cycles.
干预措施: Nilotinib and Paclitaxel
结局指标
主要结局
Objective response
时间窗: 12 months
If at least 4/30 patients experience an objective response, defined as a complete or partial response by RECIST 1.1, the combination of nilotinib and paclitaxel will be considered promising. This design provides approximately 88% power to reject a null ORR of 0.05 when the true ORR is 0.2 (with one-sided type-I error of approximately 0.062).