TO STUDY THE EFFICACY AND SAFETY OF NETARSUDIL OPHTHALMIC SOLUTION 0.02 PERCENT IN PATIENTS OF POAG.

The aim of the trial is to study the efficacy and side effects of netarsudil 0.02% eye drops in patients of primary open angle glaucoma over a periods of 3 month. The sample size would be 130 patients and the duration of the trial will be for 18 months .The type of study is randomized control trial . The eligible patients are diagnosed case of POAG who is already  taking timolol 0.5% twice daily of age 45 year and above and IOP would be between 17 and 25 mm hg with visual acuity of 6/9 or better. The patients having advanced glaucomatous changes and having any other ocular pathology which affects IOP or media clarity will be excluded from the study.

After initial examination  like visual acuity ,IOP measurement ,slit lamp examination ,gonioscopy ,fundus and  baseline investigation like OCT for RNFL analysis the randomization of patients will be done by computer allocation system in two arms . The one arm will be provide netarsudil 0.02%  once daily eye drop as a combination therapy with timolol 0.5% twice daily and the other arm will remain on monotherapy of timolol 0.5% .

The follow up visit will be at 2 week ,6 week ,3 month . The visual acuity ,IOP, slit  lamp examinations , schirmers test will be done at each visit . The fundus examination and OCT for RNFL analysis will be done at 3 month .

The primary outcome will be IOP reduction from baseline in percentage which is calculated by averaging  the mean of mean IOP measurements at 2 week ,6 week and 3 month at 9 am , 11 am and 1pm