Investigation of unusually rapid clearance of cefazoli
Not Applicable
- Conditions
- Abnormally rapid clearance of cefazolinInfection - Other infectious diseases
- Registration Number
- ACTRN12624000332527
- Lead Sponsor
- niversity of Otago
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
Abnormally low plasma cefazolin concentration despite standard dosing and/or cefazolin treatment failure not easily explained by an alternative cause
Age greater than or equal to 18 years
Resolution of index infection
Provision of informed consent to participate in the study
Able to comply with study procedures
Exclusion Criteria
Prior adverse reaction to cefazolin or any of its excipients
Poor venous access
Most recent haemoglobin concentration below 110g/L for women or 115g/L for men
Receipt of cefazolin within the last 7 days
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Area under the time-free plasma cefazolin concentration (AUC) curve after administration of a single 1g intravenous dose[Free plasma cefazolin concentrations will be measured at multiple predetermined timepoints following drug administration using a blood plasma laboratory assay. Cefazolin free plasma concentration measurements will be done at 5 minutes, 10 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 6 hours and 8 hours after drug administration. The pharmacokinetic curve produced will be used to calculate the area under the time-free plasma cefazolin concentration curve. ]
- Secondary Outcome Measures
Name Time Method Proportion of drug excreted unchanged in the urine[Collection of all urine produced in the 8 hours post drug dose for urine free cefazolin concentration measurement. Over 8 hours from the time of drug administration];Free plasma cefazolin elimination half-life[Free plasma cefazolin concentrations will be measured at multiple predetermined timepoints following drug administration using a blood plasma laboratory assay. Free plasma cefazolin concentration will be measured using a blood plasma laboratory assay at the following timepoints after cefazolin administration: 5 minutes, 10 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours. Half-life will be calculated from the pharmacokinetic curve produced.]