Beta-Alanine Supplementation in patients with COPD following an exercise training program to strengthen the lower limbs.

Recruiting

Conditions: chronic obstructive pulmonary disease
chronic lungdisease with persistent obstruction of the airways
10006436

Registration Number: NL-OMON56353

Lead Sponsor: CIRO

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 68

Inclusion Criteria

- COPD, GOLD group B or D (high symptomatic)
- Grade 3 or higher on the Modified Medical Research Council (mMRC) dyspnoea
scale
- Clinically stable according to the pulmonary physician, i.e. no exacerbation
and/or hospitalization within the previous 4 weeks.
- Age between 40-80 years
- Cycle endurance time, measured during a constant work rate test (CWRT) at 75%
of the peak cycling load, is 100-300 seconds and/or Quadriceps Muscle Strength
(peak torque), measured with a computerized dynamometer, is less than 80% of
the predicted value
- Attending the regular inpatient pulmonary rehabilitation program in CIRO and
receiving NMES as the primary muscle training modality.
- No use of anabolic steroids during the inpatient pulmonary rehabilitation
program in CIRO

Exclusion Criteria

- Instable cardiac disease
- Neurological disease and/or musculoskeletal disease that preclude safe
participation in an exercise test
- History of drugs/alcohol abuse in the past 10 years
- Vegetarianism
- Inability to understand the Dutch language
- Self-reported β-alanine supplementation in the past 3 months
- Participation in pulmonary rehabilitation within the past 12 months

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Exercise tolerance, defined as the change in cycle endurance time (before and<br /><br>after the rehabilitation period), measured during a constant work rate cycle<br /><br>test (CWRT)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Lower-limb muscle function, 6-minute walking distance, fatigue, disease<br /><br>specific quality of life, body composition, dyspnoea, symptoms of anxiety and<br /><br>depression, physical activity, problematic activities of daily life, mobility,<br /><br>cognitive function, respiratory muscle strength, systemic beta-alanine,<br /><br>carnosine, taurine and histidine, systemic inflammatory and oxidative stress<br /><br>markers, muscle beta-alanine, carnosine, taurine and histidine, muscle<br /><br>inflammation and oxidative stress and inflammatory and oxidative stress markers<br /><br>in the lungs, therapy adherence, patient safety and supplement duration. </p><br>