Identification the Cause of Cerebral Infarction in Patients With Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 118
- 试验地点
- 1
- 主要终点
- Prevalence of deep vein thrombosis and microembolic signal in cancer related stroke patients
研究概览
简要总结
Although there has been increasing interest in the association between cancer and cerebrovascular disease, the underlying pathophysiology of stroke in cancer patients is still not fully understood. The aim of this study is to investigate the stroke mechanisms in patients with cancer-associated stroke.
详细描述
Patients with cryptogenic embolic stroke will be prospectively enrolled and categorized into two groups according to the presence of active cancer: cryptogenic embolic stroke with active cancer (cancer-associated stroke) vs. without active cancer (cryptogenic embolic stroke). All patients will undergo brain MRI/MRA, 12-lead electrocardiography, transthoracic and transesophageal echocardiography with injection of agitated saline, and 24-hour Holter and/or telemonitoring. Duplex ultrasonography to detect venous thrombosis of the lower extremity will also be performed in patients with a positive right-to-left shunt on echocardiography.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects with acute ischemic stroke who presented within 7 days from symptom onset
- •Subjects who had embolic infarction outside the perforator territory revealed by diffusion-weighted imaging
- •Subjects with undetermined cause of stroke despite of initial evaluation including electrocardiogram and brain imaging upon admission
- •Subjects who performed brain magnetic resonance image (MRI) and MR angiography (MRA), cardiac work-ups (12-lead electrocardiography, transthoracic and/or transesophageal echocardiography with injection of agitated saline (or agitated saline transcranial Doppler monitoring), and 24-hour Holter and/or telemonitoring)
- •Subjects with informed consent
排除标准
- •Subjects with single subcortical infarction
- •Subjects with primary brain tumor
- •Inability to perform comprehensive studies
- •Refusal or withdrawal of the consent
结局指标
主要结局
Prevalence of deep vein thrombosis and microembolic signal in cancer related stroke patients
时间窗: Within one week after enrollment
Venous thromboembolism was investigated via Doppler sonography and/or computed tomography pulmonary angiography combined with venous phase CT angiography of the lower extremities. Microembolic signal was detected via transcranial Doppler sonography on symptomatic cerebral circulation
次要结局
- Impact of intravascular thrombosis on infarct volume(Within one week after enrollment)
- Impact of intravascular thrombosis on survival(Till the event of death occurs in enrolled patients)
研究者
Chin-Sang Chung
MD, PhD
Samsung Medical Center