Evaluation of efficacy of zoledronate gel as a local drug delivery system in the treatment of chronic pyorrhoea
- Conditions
- Health Condition 1: null- Chronic Periodontitis
- Registration Number
- CTRI/2016/05/006960
- Lead Sponsor
- Abhaya Gupta
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Systemically healthy chronic periodontitis subjects (30-50 years) having pocket probing depths (PDs) more than or equal to 5mm or clinical attachment levels (CALs) more than or equal to 4mm and vertical bone loss more than or equal to 3 mm on intraoral periapical radiographs or Orthopentomograph were initially included. Only those subjects which on screening by the dentascan showed two walled or combined defects without involving the furcation with radiographic defect angle less than or equal to 45 degrees were selected for the study by an independent blinded investigator.
Individuals allergic to bisphosphonates or on systemic bisphosphonate therapy, tobacco & alcohol users, immunocompromised patients or having taken antibiotics within preceding 3 months, undergone periodontal surgical treatment within last 6 months, pregnant or lactating females were excluded.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method full mouth plaque index , <br/ ><br>gingival index, <br/ ><br>tooth specific probing depth & clinical attachment levelTimepoint: baseline <br/ ><br>3 months <br/ ><br>6 months
- Secondary Outcome Measures
Name Time Method defect depth, <br/ ><br>bucco-lingual width of defect, <br/ ><br>mesio-distal defect width, radiographic angle fill & volumetric bone gain percentageTimepoint: baseline <br/ ><br>6 months