Nabothian Cyst Protects or Facilitates Against Cervical Cancer

• Conditions: HPV Infection; Nabothian Cyst; Cervical Cancer
• Interventions: Other: Cervical Cancer Rate

• Registration Number: NCT04488991
• Lead Sponsor: Haseki Training and Research Hospital

Brief Summary

Aim of the study to asses the realition between HPV infection, Nabothian Cyst and Cervical Intraepithelial lesions or Cervical Cancer

Detailed Description

Nabothian cysts are one of the common gynecological pathologies. They rarely have clinical significance. Transvaginal ultrasonography and magnetic resonance imaging are the most useful imaging methods for cervical cystic lesions.HPV infection is the most important factor which can cause cervical malignancy and premalignant lesions. In women between 30-65 years of age HPV-DNA testing, is used as a screening test in Turkey. In this research, the aim is to examine whether there is a connection between Naboth cysts and HPV infection in the cervix. During the examination, the swab sample required for HPV PCR testing will be taken. The number and size of Naboth cysts with vaginal USG will be noted. If the patient had colposcopy / LEEP (Loop Electrosurgical Excision Procedure), the result will be investigated and noted.

Study Timeline

• Status Verified: 2020-07
• Study First Submitted: 2020-07-16
• Study Start: 2020-07-23
• Study First Submitted QC: 2020-07-24
• Last Update Submitted: 2020-07-24
• Study First Posted: 2020-07-28
• Last Update Posted: 2020-07-28
• Primary Completion: 2021-03-01
• Study Completion: 2021-03-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 1005

Inclusion Criteria

To have Naboth cyst and/or HPV positivity Must be willing and able to provide informed consent Comply with the study protocol Between 25-65 age range

Exclusion Criteria

To Refuse participate in our research The age under 25 and over 65 Ovarian, endometrial and vulvar malignancies Without both Naboth's cyst and HPV positivity To have LEEP/Cervical Conization before History of Cervical Dysplasia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
the woman who has just HPV infection	Cervical Cancer Rate	the woman who is between 30-65 years old, who is participate this research, and has just HPV infection in cervix.
the woman who has just nabothian cyst	Cervical Cancer Rate	the woman who is between 30-65 years old, who is participate this research, and has just nabothian cyst in cervix.
the woman who has both nabothian cyst and HPV infection	Cervical Cancer Rate	the woman who is between 30-65 years old, who is participate this research, and has both nabothian cyst in cervix.

Primary Outcome Measures

Name	Time	Method
Nabothian cyst affects the HPV infection in cervix	through study completion, an average of 1 year	in the research, results will be compared for to figure out the relation; nabothian cyst how affects HPV infection , how causes cervical dysplasia in cervix.

Secondary Outcome Measures

Name	Time	Method
Does the other factors(like cigarette, birth number, vaginitis) affect HPV infection and Cervical Cancer	through study completion, an average of 1 year	In the research Other factors(like cigarette, birth number, vaginitis) will be also noted. These datas will be used to understand correlation; the other factors increase or decreate the rate of HPV infection and cervical dysplasia.

Trial Locations

Locations (1)

Cihan Comba; 🇹🇷 Istanbul, Sultangazi, Turkey