Comparison of Different Modalities in Reducing Airborne Particulate Concentrations During Aerosol Generating Procedures for Health Volunteers: a Randomized Cross-over Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- aerosol particle concentrations at 1 foot away from subject's face
研究概览
简要总结
Several clinical procedures have been described as aerosol generating procedure (AGP), including nebulization, high-flow nasal cannula oxygen therapy, noninvasive ventilation, and bronchial hygiene treatment, etc. However, the understanding on the transmission risk of these treatments is still unclear, particularly the methods to reduce the airborne particulate concentrations during these treatments are still lacking. This study is aimed to compare different modalities in reducing airborne particulate concentrations during these aerosol generating procedures, in order to find the most effective method to reduce particle concentrations, ultimately to decrease the transmission risk and protect health care providers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ages 18-65, Male or Female
排除标准
- •Chronic lung disease, including asthma, COPD, etc.
- •Upper airway anatomical abnormities
- •Pregnancy
- •Uncontrolled Diabetes, hypertension, or untreated thyroid disease
- •Has any of the following symptoms in the last 21 days: sore throat, cough, chills, body aches for unknown reasons, shortness of breath for unknown reasons, loss of smell, loss of taste, fever at or greater than 100 degrees Fahrenheit.
- •COVID-19 test positive within 21 days.
研究组 & 干预措施
Nebulization without filter or scavenger
Subject will use a standard nebulizer
Nebulization with a filter or scavenger
Subject will use a nebulizer with a filter placed at the other end of nebulizer mouthpice or a scavenger outside the nebulizer mask
干预措施: Filter (Device)
Nebulization with a filter or scavenger
Subject will use a nebulizer with a filter placed at the other end of nebulizer mouthpice or a scavenger outside the nebulizer mask
干预措施: Scavenger face tent (Device)
High-flow nasal cannula
Subject will use high-flow nasal cannula at 40 L/min
High-flow nasal cannula with a scavenger face tent
Subject will use high-flow nasal cannula at 40 L/min, with a scavenger face tent
干预措施: Scavenger face tent (Device)
High-flow nasal cannula with a surgical mask
Subject will use high-flow nasal cannula at 40 L/min, with a surgical mask over nasal cannula
干预措施: Filter (Device)
结局指标
主要结局
aerosol particle concentrations at 1 foot away from subject's face
时间窗: 5 mins
aerosol particle concentrations will be recorded continuously for 5 mins during the use of each device at 1 foot away from subject's face
aerosol particle concentrations at 3 feet away from subject's face
时间窗: 5 mins
aerosol particle concentrations will be recorded continuously for 5 mins during the use of each device at 3 feet away from subject's face
次要结局
- subject's comfort(5 minutes after using the device)