EVALUATION OF THE ACCEPTABILITY AND EFFICACY OF 10 MICROGRAMS OF ESTRADIOL VAGINAL TABLETS VS PROMESTRIENE VAGINAL CREAM

Instituto Palacios0 个研究点目标入组 120 人开始时间: 2019年12月2日最近更新: 2020年2月1日

适应症

试验速览

暂无简介。

•Postmenopausal women aged 45 years or older. Women will be considered postmenopausal with more than 12 months since last menstrual period
•Women who have read and signed the Informed Consent Form
•Women with an intact uterus
•One or more vaginal symptoms (dryness, soreness, irritation, dyspareunia) rated as moderate to severe. Symptoms are moderate if the patient needs a treatment and feels discomfort. Symptoms are severe if the patient needs a treatment, and feels such a degree of discomfort that this could severely impact the subject’s daily activities.
•Blood estradiol concentration of 30 pg/ml or less .
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 120
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•Women who have not signed the Informed consent Form
•Women who had a known or suspected history of breast carcinoma
•Estrogen dependent neoplasia. Women with a known, past or suspected Estrogen-dependent malignant tumours such as endormetrial or ovarian cancer
•Positive or suspicious mammogram results
•Any systemic malignant disease
•Hormone therapy treatment (sex hormones or vaginal treatments or steroids) in the last three months
•Women who had abnormal vaginal bleeding or uterine bleeding of unknown cause
•Vaginal infection requiring treatment
•Previous or current venous thromboembolism (deep venous thrombosis, pulmonary embolism) Untreated endometrial hyperplasia Known thrombophilic disorders (e.g. protein C, protein S, or antithrombin deficiency) Active or previous arterial thromboembolic disease (e.g. angina, myocardial infarction) Acute liver disease, or history of liver disease as long as liver function tests have failed to return to normal Known Hypersensitivity to the active substances or to any of the excipients Porphyria
•Any serious disease or chronic condition that could interfere with study compliance
•History of thrombolytic disorders
•Use of vaginal contraceptives (DIU, vaginal ring…)
•Participation in another clinical trial in the last three months.

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