Acute Responses to Manipulating Dietary Carbohydrate Content on Free-living Physical Activity Energy Expenditure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- Physical activity energy expenditure (kj/day or kcal/day)
研究概览
简要总结
Dietary sugar and carbohydrate intakes will be manipulated for 3 days in a randomised crossover design. All food will be provided. Free-living physical activity energy expenditure will be measured using combined heart rate and accelerometry. Metabolic and appetite/mood responses to 3 days on each diet will be measured.
Each participant will undergo 3 days of each diet:
- Moderate sugar - reflecting the composition of a typical European diet
- Low sugar - similar macronutrient composition of a typical European diet but with <5% energy intake from free sugars (as per government guidelines)
- Low carbohydrate - low carbohydrate diet with <5% energy intake from sugar and <8% energy intake from carbohydrate, replacing carbohydrate energy with fat
详细描述
Guidelines calling for dietary free sugars to be reduced have been formulated from evidence that diets high in sugar are associated with high energy intake. In theory, by reducing the intake of sugars, calorie surplus will be reduced and energy balance will be maintained. However, when referring to interventions/behaviours that influence energy balance, both sides of the energy balance equation need to be considered. Alterations in nutrients may influence aspects of energy expenditure, not solely energy intake, and this may have implications for the efficacy of guidelines seeking to influence energy intake.
It is important to consider energy expenditure in the context of health. The most variable component of energy expenditure between individuals is physical activity energy expenditure (PAEE), which varies from ~600-2100 kcal per day in men of a similar demographic. Current guidelines do not regard the effect that changing dietary sugar might have on PAEE and therefore total energy expenditure.
Furthermore, there is increasing interest in restricting overall carbohydrate intake to treat metabolic disease or achieve ketogenesis. Very little is known about nutrition-physical activity interactions with this type of intervention.
This study will prescribe 3 diets to healthy males for 3 days in a randomised crossover design, where each participant will consume each of the diets. All food will be prepared and provided by the study team. The diets are as follows:
- Moderate sugar - reflecting the composition of a typical European diet
- Low sugar - similar macronutrient composition of a typical European diet but with <5% energy intake from free sugars (as per government guidelines)
- Low carbohydrate - low carbohydrate diet with <5% energy intake from sugar and <8% energy intake from carbohydrate, replacing carbohydrate energy with fat
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Body mass index 18.5-29.9 kg∙m-2
- •Age 18-65 years
- •Able and willing to provide informed consent and safely comply with study procedures
- •No anticipated changes in physical activity during the study (e.g. holidays)
排除标准
- •Any reported condition or behaviour deemed either to pose undue personal risk to the participant or introduce bias
- •Any diagnosed metabolic disease (e.g. type 1 or type 2 diabetes)•Any reported use of substances which may pose undue personal risk to the participants or introduce bias into the experiment
- •Lifestyle not conforming to standard sleep-wake cycle (e.g. shift worker)
- •Any reported recent (<6 months) change in body mass (±3%)
结局指标
主要结局
Physical activity energy expenditure (kj/day or kcal/day)
时间窗: 3 days
Physical activity energy expenditure measured using individually-calibrated combined heart rate and accelerometry (kj/day or kcal/day)
次要结局
- Fasting blood lactate concentrations(3 days)
- Fasting blood fibroblast growth factor-21 concentrations(3 days)
- Fasting blood high density lipoprotein concentrations(3 days)
- Fasting blood beta-hydroxybutyrate concentrations(3 days)
- Food preference ratings(3 days)
- Subjective appetite and mood ratings(3 days)
- Fasting blood leptin concentrations(3 days)
- Fasting blood insulin concentrations(3 days)
- Fasting blood triglyceride concentrations(3 days)
- Energy expended in different physical activity intensities (MET categories) (kJ/day or kcal/day)(3 days)
- Fasting blood glucose concentrations(3 days)
- Fasting blood total cholesterol concentrations(3 days)
- Blood pressure(3 days)
- Time spent in different physical activity intensities (MET categories) (minutes)(3 days)
- Energy expended in the postprandial period (kJ or kcal)(3 days)
- Fasting blood non-esterified fatty acid concentrations(3 days)
- Fasting blood low density lipoprotein concentrations(3 days)
研究者
Javier Gonzalez
Senior Lecturer
University of Bath