Desmopressin melt therapy in nocturnal polyuria patients: pharmacodynamic study

Ghent University Hospital0 个研究点目标入组 5 人开始时间: 2011年9月14日最近更新: 2021年8月10日

适应症

试验速览

暂无简介。

•- Written informed consent prior to the performance of any study-related activity
•- Patients 18 years and older with an average of = 2 nocturnal voids per night
•- Evidence for nocturnal polyuria (nocturnal urine volume >33% of total volume over 24h), determined on frequency/volume chart
•- Diuresis < 2,5L
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 40
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 10

•- hypersensitivity/anaphylactic reaction on desmopressin or one of the other substances
•- pregnancy
•- genito-urinary tract pathology (infection, tumor,...)
•- urolithiasis
•- suspicion or evidence of cardiac failure
•- suspicion or evidence of liver failure
•- moderate to severe renal insufficiency (creatinin clearance < 60 ml/min)
•- psychogenic or habitual polydipsia
•- hyponatriemia or predisposition for hyponatriemia (sodium < 135 mmol/L) before inclusion
•- diabetes insipidus
•- syndrome of inadequate ADH production

发起方