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Clinical Trials/DRKS00000115
DRKS00000115
Completed
Phase 2

Effect and Safety of preventive Treatment with ACE-Inhibitor and Beta-Blocker on the onset of Left Ventricular Dysfunction in Duchenne Muscular Dystrophy - DMD Kardio

Friedrich- Alexander- Universität Erlangen Nürnberg,Universitätsklinikum , Dekan0 sites42 target enrollmentNovember 18, 2009
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ConditionsI50Heart failure

Overview

Phase
Phase 2
Intervention
Not specified
Conditions
I50
Sponsor
Friedrich- Alexander- Universität Erlangen Nürnberg,Universitätsklinikum , Dekan
Enrollment
42
Status
Completed
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
November 18, 2009
End Date
December 11, 2015
Last Updated
last year
Study Type
Interventional
Sex
Male

Investigators

Sponsor
Friedrich- Alexander- Universität Erlangen Nürnberg,Universitätsklinikum , Dekan

Eligibility Criteria

Inclusion Criteria

  • •1\. Male patients aged 10 \- 14 years
  • •2\. Normal left ventricular function (LVSF \>\=30%)
  • •3\. DMD confirmed by genetic analysis (muscle biopsy facultative)
  • •4\. Normal renal function (GFR \>30 ml/min/1,73 m2\)
  • •5\. Informed Consent of both parents, assent of patient

Exclusion Criteria

  • •1\. Contraindications for ACE\-Inhibitors/Beta\-Blocker.
  • •2\. Previous therapy with ACE\-Inhibitors, AT II Antagonists, Beta\-Blockers in the past 3 Months.
  • •3\. Participation in another one clinical Trial parallel to this clinical trial
  • •4\.Dilated left ventricle ( \> 97 percentile) or reduced LVSF \< 30%

Outcomes

Primary Outcomes

Not specified

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