The PLUG Study – A Feasibility Study Investigating the Prevention of Post-operative Gastro-oesophageal Anastomotic Leaks with the use of a Surgical Adhesive, BioGlue
Not Applicable
- Conditions
- Gastro-oesophageal surgerySurgery
- Registration Number
- ISRCTN26729280
- Lead Sponsor
- Portsmouth Hospitals NHS Trust
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Stopped
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
1. NHS patients undergoing elective minimally invasive oesophagectomy for cancer
2. Aged 18 years and above
3. Able to provide informed consent
Exclusion Criteria
Previous adverse reaction to BioGlue or one of its constituent ingredients
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms does BioGlue utilize to prevent gastro-oesophageal anastomotic leaks in surgical settings?
How does the use of BioGlue in the PLUG study compare to standard-of-care techniques for gastro-oesophageal anastomosis leak prevention?
Are there specific biomarkers or patient characteristics that could predict the effectiveness of BioGlue in preventing post-operative leaks in gastro-oesophageal surgery?
What are the potential adverse events associated with BioGlue application in gastro-oesophageal anastomosis, and how are they managed?
What are the current developments in surgical adhesives for anastomotic leak prevention, and how does BioGlue compare to other compounds like fibrin sealants or cyanoacrylates?