Statins & nutraceuticals to prevent cardiovascular ageing

Phase 3

Withdrawn

• Conditions: Cardiovascular disease; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12618000692235
• Lead Sponsor: Curtin University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-04-27
• Last Update Posted: 15 July 2019

Recruitment & Eligibility

• Status: Withdrawn
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

Participants aged 50-70 years of age and who are at moderate risk of CVD will be recruited. Moderate risk will be defined as having one or more of the following:
1.Hypertension (mean clinic systolic > 135 mmHg, or diastolic > 85 mmHg, or treatment)
2.Dyslipidaemia (fasting total cholesterol > 5.5 mmol/L, or LDL > 2 mmol/L, or triglycerides > 1.5 mmol/L)
3.Central obesity (men > 100 cm and women > 89 cm)
4.Hyperglycaemia (fasting glucose > 5.5 mmol/L or treatment)
5.Overweight (BMI > 27)
6.A score of 10-15% as calculated by the Australian Absolute Cardiovascular Disease Risk Score calculator

Exclusion Criteria

•Previous known statin intolerance
•Current use of statin therapy
•Pregnant or lactating women
•BMI >35 kg/m2
•Any adult with a previous diagnosis of a severe co-existing medical condition that would prevent participation (e.g. severe dementia or terminal illness)
•Alcohol intake >3 standard drinks a day (men) or >2 standard drinks a day (women)
•Vegetarian, vegan or previous gastric banding surgery
•Current use of prebiotic or probiotic medications
•Recent use of antibiotics (<3 months)
•Current smoker or quit smoking within the last 3 months
•Unable to give informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified