Anterior Segment Changes After Pars Plana Vitrectomy With SO Using AS-OCT

Completed

• Conditions: Glaucoma
• Interventions: Device: AS-OCT after vitrectomy

• Registration Number: NCT06524661
• Lead Sponsor: Minia University

Brief Summary

To evaluate changes in ACA induced by pars plana vitrectomy with SO 1000cs injection in vitreo-retinal surgery in phakic eyes using AS-OCT and changes in the IOP preoperatively, post-operatively and post-silicone oil evacuation.

Detailed Description

Abstract Introduction Ocular hypertension and secondary glaucoma are relatively common and serious complications in silicone filled eyes which may end in blindness. Reports have described the percentage of incidence to be within 3 - 30 % of silicon filled eye which are complicated with secondary glaucoma. \[1\] Aim of study Evaluation of changes in anterior chamber angle and intra-ocular pressure (IOP) in patients with rhegmatogenous retinal detachment (RRD) who underwent pars plana vitrectomy (PPV) with silicone oil (SO) 1000cs tamponade and after silicone oil evacuation.

Population The study was a prospective interventional study. The study included 30 eyes from 30 patients with rhegmatogenous retinal detachment (RRD) who are going to undergo PPV with SO injection. The study was conducted at Ophthalmology department, Minia University Hospital in Egypt between April 2023 and April 2024.

Study Timeline

• Study Start: 2023-04-15
• Primary Completion: 2024-04-15
• Study Completion: 2024-04-15
• Status Verified: 2024-07
• Study First Submitted: 2024-07-19
• Study First Submitted QC: 2024-07-26
• Last Update Submitted: 2024-07-26
• Study First Posted: 2024-07-29
• Last Update Posted: 2024-07-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• • Patients with rhegmatogenous retinal detachment who are going to undergo vitreoretinal surgery with silicone oil 1000cs injection as tamponade

Exclusion Criteria

• Patients with history of intraocular surgery, laser therapy or intravitreal injection.
• Patients with significant corneal opacity.
• Patients with ocular diseases as retinal vein occlusion, uveitis and proliferative diabetic retinopathy.
• Patients with preexisting glaucoma or family history of glaucoma.
• Patients with nystagmus.
• Patient with tractional retinal detachment, exudative retinal detachment or intraocular foreign body.
• Patients with anterior chamber abnormalities including posterior synechia, peripheral anterior synechia, hyphaema and iris abnormalities.
• Patients with severe proliferative vitreoretinopathy grade C or more.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with RRD who underwent pars plana vitrectomy with	AS-OCT after vitrectomy	AS-oct measuring the anterior chamber angle and corneal changes after pars plana vitrectomy with silicone oil 1000cs injection

Primary Outcome Measures

Name	Time	Method
Assessement of the changes in anterior chamber angle after vitrectomy with silicone oil injection	postoperative evaluation for 3 months duration (5 visits pre-ppv then one week, one month, three months )	Evaluation of changes in the anterior chamber angle parameters after vitrectomy with silicone oil 1000cs injection.; The measures include AOD 500, TISA 500, ACA and CCT The measuring tool is AS-OCT (anterior segment optical coherent topography)

Trial Locations

Locations (1)

Faculty of medicine ,Minia university; 🇪🇬 Minya, Egypt