Prone Positioning in COVID-19 Patients

Not Applicable

• Conditions: Mechanical Ventilation Pressure High; Coronavirus Disease 2019; ARDS

• Registration Number: NCT05150847
• Lead Sponsor: Tepecik Training and Research Hospital

Brief Summary

Prone positioning improves oxygenation in patients with ARDS (1-3). Patients with severe ARDS due to COVID-19 are candidates for prone position. It should be started within 36-48 h and maintained 1, 3). Prone ventilationARDS based on a randomized trial that showed a mortality benefit (PROSEVA) (3).

The improvement of oxygenation occurs by making ventilation more homogeneous, limiting ventilator-associated lung injury (4-6).

Prone positioning was as effective in improving oxygenation, static respiratory system compliance (Crs) (7).

Higher PEEP should be applied when there is a high recruitability potential of the lung. This study aimed to investigate whether prone positioning changes the recruitability position of the lung.in COVID-ARDS.

Detailed Description

Prone positioning improves oxygenation in patients with ARDS (1-3). Patients with severe ARDS due to COVID-19 are candidates for prone position. It should be started within 36-48 h and maintained 1, 3). Prone ventilationARDS based on a randomized trial that showed a mortality benefit (PROSEVA) (3).

The improvement of oxygenation occurs by making ventilation more homogeneous, limiting ventilator-associated lung injury (4-6).

Prone positioning was as effective in improving oxygenation, static respiratory system compliance (Crs) (7).Higher PEEP should be applied when there is a high recruitability potential of the lung. This study aimed to investigate whether prone positioning changes the oxygenation, respiratory mechanics and recruitability position of the lung in COVID-ARDS.

Study Timeline

• Study First Submitted: 2021-12-07
• Study First Submitted QC: 2021-12-07
• Study First Posted: 2021-12-09
• Study Start: 2021-12-25
• Status Verified: 2022-01
• Last Update Submitted: 2022-01-31
• Primary Completion: 2022-02-01
• Last Update Posted: 2022-02-01
• Study Completion: 2022-04-13

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Adult patients with laboratory-confirmed COVID-19 admitted to the ICU
• The patients receive invasive mechanical ventilation and meet the criteria for ARDS (Berlin definition) (8), with under continuous infusion of sedatives,

Exclusion Criteria

• Pregnancy
• Pneumothorax and or chest tube
• Chronic obstructive lung disease
• interstitial lung disease
• intraabdominal hypertension
• increase in intracranial blood pressure
• Haemodynamic unstability requiring vasopressors

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Oxygenation	intubation + 48 hours	PaO2/FiO2

Secondary Outcome Measures

Name	Time	Method
Recruitability	intubation + 48 hours	recruitment to inflation ratio
Static compliance	intubation + 48 hours	Tidal volume divided driving pressure

Trial Locations

Locations (1)

Kazim Rollas; 🇹🇷 İzmir, Turkey