The Effect of Prone Positioning on Oxygenation and Respiratory Mechanics in Patients With COVID-19 Pneumonia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Coronavirus Disease 2019
- Sponsor
- Tepecik Training and Research Hospital
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Oxygenation
- Last Updated
- 4 years ago
Overview
Brief Summary
Prone positioning improves oxygenation in patients with ARDS (1-3). Patients with severe ARDS due to COVID-19 are candidates for prone position. It should be started within 36-48 h and maintained 1, 3). Prone ventilationARDS based on a randomized trial that showed a mortality benefit (PROSEVA) (3).
The improvement of oxygenation occurs by making ventilation more homogeneous, limiting ventilator-associated lung injury (4-6).
Prone positioning was as effective in improving oxygenation, static respiratory system compliance (Crs) (7).
Higher PEEP should be applied when there is a high recruitability potential of the lung. This study aimed to investigate whether prone positioning changes the recruitability position of the lung.in COVID-ARDS.
Detailed Description
Prone positioning improves oxygenation in patients with ARDS (1-3). Patients with severe ARDS due to COVID-19 are candidates for prone position. It should be started within 36-48 h and maintained 1, 3). Prone ventilationARDS based on a randomized trial that showed a mortality benefit (PROSEVA) (3). The improvement of oxygenation occurs by making ventilation more homogeneous, limiting ventilator-associated lung injury (4-6). Prone positioning was as effective in improving oxygenation, static respiratory system compliance (Crs) (7).Higher PEEP should be applied when there is a high recruitability potential of the lung. This study aimed to investigate whether prone positioning changes the oxygenation, respiratory mechanics and recruitability position of the lung in COVID-ARDS.
Investigators
Kazim Rollas
Intensive Care Specialist, Principal Investigator
Tepecik Training and Research Hospital
Eligibility Criteria
Inclusion Criteria
- •Adult patients with laboratory-confirmed COVID-19 admitted to the ICU
- •The patients receive invasive mechanical ventilation and meet the criteria for ARDS (Berlin definition) (8), with under continuous infusion of sedatives,
Exclusion Criteria
- •Pregnancy
- •Pneumothorax and or chest tube
- •Chronic obstructive lung disease
- •interstitial lung disease
- •intraabdominal hypertension
- •increase in intracranial blood pressure
- •Haemodynamic unstability requiring vasopressors
Outcomes
Primary Outcomes
Oxygenation
Time Frame: intubation + 48 hours
PaO2/FiO2
Secondary Outcomes
- Static compliance(intubation + 48 hours)
- Recruitability(intubation + 48 hours)