EUCTR2005-001466-14-GB进行中（未招募）1 期
A Proof of Concept Study to Investigate the use of Simvastatin as a Putative Anti-inflammatory Agent in Asthma - Simvastatin in Asthma
niversity of Dundee0 个研究点目标入组 20 人开始时间: 2005年4月19日最近更新:
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •Adult asthmatics (over 18 years) with stable mild to moderate asthma.
- •FEV1 > 60%
- •FENO > 20ppb
- •MCh PC10 < 2mg/mL
- •Induced sputum eosinophil count >3%
- •Ability to perform tests and remain compliant with protocol
- •Good inhaler technique
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range
排除标准
- •Potential or actual contra-indication to Simvastatin in particular liver disease, renal failure, current or previous excess alcohol intake, elevated CK, pregnancy and concomitant use of medications known to interact adversly with simvastatin.
- •Known or suspoected hypersensitivity to any of the other IMP's
- •Inability to to provide informed consent
- •Recent respiratory tract infection
- •Recent use of oral corticosteroids
- •Significant concomitant respiratory disease
- •Current smokers
- •Any other condition that may, in the opinion of the investigators, endanger the health or safety of the participant
研究者
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