NCT00726726已完成1 期
Effect of Concomitant Administration of BMS-708163 on the Pharmacokinetics of Midazolam, Warfarin, Caffeine, Omeprazole and Dextromethorphan in Healthy Male Subjects by Administration of a Modified Cooperstown Cocktail
Bristol-Myers Squibb1 个研究点 分布在 1 个国家目标入组 22 人开始时间: 2008年8月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Pharmacokinetic effects of BMS-708163 on interacting drugs (midazolam, warfarin, caffeine, omeprazole, and dextromethorphan)
研究概览
简要总结
The purpose of this study is to determine whether BMS-708163 will effect the pharmacokinetics of the commonly prescribed medicines midazolam, warfarin, caffeine,omeprazole and dextromethorphan
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy male subjects
- •18-45 yrs old inclusive
排除标准
- 未提供
研究组 & 干预措施
B
Experimental
干预措施: BMS-708163 (Drug)
A
Other
干预措施: Interacting drugs - Cooperstown Cocktail (midazolam, warfarin, (+ vitamin K), caffeine, omeprazole and dextromethorphan) (Drug)
C
Experimental
- Other
干预措施: BMS-708163 + Cooperstown Cocktail (Drug)
结局指标
主要结局
Pharmacokinetic effects of BMS-708163 on interacting drugs (midazolam, warfarin, caffeine, omeprazole, and dextromethorphan)
时间窗: throughout the study
次要结局
- Safety variables (adverse events, vital signs, safety labs)(throughout the study)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
1 期
Study of Combined Oral Contraceptive Effects in Female SubjectsInfection, Human Immunodeficiency VirusNCT02157467ViiV Healthcare46
已完成
1 期
The Effect of BMS-986165 Combined With an Oral Contraceptive (Ethinyl Estradiol/Norethindrone) in Healthy Female PatientsArthritic PsoriasisPsoriasisInflammatory Bowel DiseasesSystemic Lupus ErythematosusNCT03262727Bristol-Myers Squibb49
已完成
1 期
Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of BMS-708163Alzheimer's DiseaseNCT01079819Bristol-Myers Squibb32
已完成
1 期
Study to Assess the Effect of BMS-790052 on the Pharmacokinetics of Ortho Tri-Cyclen® in Healthy Female SubjectsChronic Hepatitis CNCT00983957Bristol-Myers Squibb47
已完成
1 期
The Effect of BMS-986195 Combined With an Oral Contraceptive (Ethinyl Estradiol/Norethindrone) in Healthy Female PatientsRheumatoid ArthritisNCT03262740Bristol-Myers Squibb58