"Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial."
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 50
- 主要终点
- Alanine aminotransferase
研究概览
简要总结
Aim:
To evaluate effect of non- surgical periodontal therapy on liver function in systemically healthy chronic periodontitis (CP) subjects.
Materials and methods:
The study is non surgical interventional trial, includes 50 CP subjects in the age group of 35- 60 years selected from the OPD (Out Patient Department) of department of periodontology Tatyasaheb Kore Dental College and Research center (TKDC and RC), Kolhapur. CP subjects were equally divided into test group and control group. Liver function test- aspartate aminotransferase (AST), alanine aminotransferase (ALT) were checked at baseline and at 1 month after treatment. Clinical examination includes plaque index, gingival index, sulcus bleeding index, probing depth, clinical attachment loss.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 35 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects with CP (moderate and severe) as per Centers for disease control and prevention (CDC) criteria
- •Patients without any known systemic diseases
排除标准
- •Patients who have taken anti-inflammatory/antibiotic/antioxidant within 3 months of beginning of study.
- •Subjects who have undergone periodontal treatment within six months of inception of study.
- •Smokers, tobacco habits in any form and alcoholics.
- •Pregnant and lactating women.
结局指标
主要结局
Alanine aminotransferase
时间窗: 1month
Aspartate aminotransferase
时间窗: 1 month
次要结局
- plaque index(1month)
- gingival index(1 month)
- sulcus bleeding index(1month)
- probing depth(1month)
- Clinical attachment loss(1 month)
研究者
Dr. Pradnya Rajendra Khatavkar
Post graduate student
Tatyasaheb Kore Dental College