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临床试验/NCT03546790
NCT03546790已完成1 期

Laboratory Smoking of Marijuana "Blunts"

Battelle Memorial Institute1 个研究点 分布在 1 个国家目标入组 8 人开始时间: 2019年4月10日最近更新:
适应症
干预措施
相关药物

试验速览

阶段
1 期
状态
已完成
入组人数
8
试验地点
1
主要终点
Puff topography

研究概览

简要总结

This is a double-blind within-subjects clinical laboratory study comparing the product appeal and abuse liability-related subjective effects of different flavored cigar wrappers for marijuana blunts.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
Triple (Participant, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 55 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Currently living in Baltimore City or Baltimore County, MD;
  • Able to read, understand, and sign informed consent;
  • 18-55 years old;
  • Currently smokes marijuana blunts;
  • Designation of Medically Healthy for Research by the Study Physician; and
  • Willing to abstain from illicit drug use other than marijuana for the duration of the study.

排除标准

  • BAC > 0.020% as measured by alcohol breathalyzer;
  • Meets DSM-5 criteria for severe current or lifetime Cannabis Use Disorder;
  • Meets DSM-5 criteria for any current Axis I disorder, other than current mild or moderate Cannabis Use Disorder;
  • Self-reported current desire to stop marijuana use;
  • Self-reported current asthma, chronic obstructive pulmonary disease, hypertension, cardiovascular disease or any other medical illness that precludes participation;
  • Has difficulties with blood draws or poor venous access;
  • History of blood donation in the past 30 days or receiving blood products within the past 2 months prior to any experimental visit;
  • Among females, current pregnancy or lactation or attempting to get pregnant, or at risk of becoming pregnant;
  • Acute illness which will require participant to be rescheduled

研究组 & 干预措施

Flavor 1

Experimental

Grape flavored tobacco cigar wrapper

干预措施: Marijuana (Drug)

Flavor 2

Experimental

Chocolate flavored tobacco cigar wrapper

干预措施: Marijuana (Drug)

Flavor 3

Experimental

Tobacco flavored tobacco cigar wrapper

干预措施: Marijuana (Drug)

结局指标

主要结局

Puff topography

时间窗: During marijuana blunt smoking

Total inhalation volume

次要结局

  • Carbon monoxide(Immediately after marijuana blunt smoking)
  • Subjective drug effects(Immediately after marijuana blunt smoking)
  • Measures of demand(Immediately after marijuana blunt smoking)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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