NCT03546790已完成1 期
Laboratory Smoking of Marijuana "Blunts"
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- Puff topography
研究概览
简要总结
This is a double-blind within-subjects clinical laboratory study comparing the product appeal and abuse liability-related subjective effects of different flavored cigar wrappers for marijuana blunts.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Currently living in Baltimore City or Baltimore County, MD;
- •Able to read, understand, and sign informed consent;
- •18-55 years old;
- •Currently smokes marijuana blunts;
- •Designation of Medically Healthy for Research by the Study Physician; and
- •Willing to abstain from illicit drug use other than marijuana for the duration of the study.
排除标准
- •BAC > 0.020% as measured by alcohol breathalyzer;
- •Meets DSM-5 criteria for severe current or lifetime Cannabis Use Disorder;
- •Meets DSM-5 criteria for any current Axis I disorder, other than current mild or moderate Cannabis Use Disorder;
- •Self-reported current desire to stop marijuana use;
- •Self-reported current asthma, chronic obstructive pulmonary disease, hypertension, cardiovascular disease or any other medical illness that precludes participation;
- •Has difficulties with blood draws or poor venous access;
- •History of blood donation in the past 30 days or receiving blood products within the past 2 months prior to any experimental visit;
- •Among females, current pregnancy or lactation or attempting to get pregnant, or at risk of becoming pregnant;
- •Acute illness which will require participant to be rescheduled
研究组 & 干预措施
Flavor 1
Experimental
Grape flavored tobacco cigar wrapper
干预措施: Marijuana (Drug)
Flavor 2
Experimental
Chocolate flavored tobacco cigar wrapper
干预措施: Marijuana (Drug)
Flavor 3
Experimental
Tobacco flavored tobacco cigar wrapper
干预措施: Marijuana (Drug)
结局指标
主要结局
Puff topography
时间窗: During marijuana blunt smoking
Total inhalation volume
次要结局
- Carbon monoxide(Immediately after marijuana blunt smoking)
- Subjective drug effects(Immediately after marijuana blunt smoking)
- Measures of demand(Immediately after marijuana blunt smoking)
研究者
研究点 (1)
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