Behavioral Economic Purchasing Decisions for Cigarettes of Varied Compositions
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 76
- 试验地点
- 2
- 主要终点
- Demand Intensity: Number of cigarette puffs obtained at the lowest fixed ratio value
研究概览
简要总结
The purpose of this study is to determine whether the abuse liability of cigarettes with altered composition (cigarettes differing in composition; e.g., tar levels, amount of sugar, casings) is reduced relative to standard composition cigarettes.
详细描述
The proposed study will determine the abuse liability of altered composition cigarettes compared to standard cigarettes using a behavioral economics abuse-liability approach. Behavioral economic demand analysis constitutes a comprehensive examination of drug reinforcement and abuse liability. Laboratory determination of cigarette consumption under various response requirements will occur before and after 3 weeks of at-home exposure, with participants randomized to cigarettes varying in composition to determine the role of experience on the abuse-liability of various cigarettes. Abuse liability will be assessed by 2 essential demand metrics: lower demand intensity and increased demand elasticity, as well as other demand metrics and subjective ratings of "liking". The study will also determine the degree to which altered composition cigarettes may substitute for standard composition cigarettes - testing whether an altered composition policy would achieve the goal of reducing standard cigarette consumption.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 years or older
- •Smoke at least five cigarettes per day
- •Have an expired carbon monoxide level of more than 8 ppm or a urinary cotinine level of more than 100 ng per milliliter
- •Have a Fagerström Test for Nicotine Dependence score of at least 5 upon screening
排除标准
- •The intention to quit smoking in the next 30 days
- •The use of other tobacco products in addition to machine-manufactured cigarettes on more than 9 of the previous 30 days
- •Use of "roll your own" cigarettes as an exclusive form of smoking
- •A serious medical or psychiatric disorder or unstable condition
- •Any positive toxicological screening for illicit drugs other than cannabis will be excluded
- •Women who are pregnant, plan to become pregnant or are breast-feeding
结局指标
主要结局
Demand Intensity: Number of cigarette puffs obtained at the lowest fixed ratio value
时间窗: 3 weeks after initiation of home exposure period
The primary behavioral economic demand curve metric (demand intensity, i.e., number of cigarette puffs obtained at the lowest fixed ratio value assessed) derived from cigarette consumption in the laboratory
次要结局
未报告次要终点