Early Recurrent Ischemic Lesions (ERILs) and Silent Neurologic Ischemic Lesions (SNILs) in Diffusion-weighted Magnetic Resonance Imaging (DW-MRI) - a Pilot- Observational Study Under Standard of Care (SOC)
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- 1. How many ERILs occur in caucasian patients with LAA stroke during 7 days on standard treatment?
研究概览
简要总结
- How many ERILs occur in caucasian patients with LAA stroke during 7 days on standard treatment?
- How many SNILs occur between 7 and 30 days after acute ischemic event on standard treatment?
- How many of during acute event diagnosed lesions (ERILs) are (still) detectable after 30 days?
- Are there relevant risk faktors for the occurence of ERILs and SNILs (eg Diabetes or Biomarkers)?
详细描述
In this trial, patients will be observed if they develop early recurrent ischemic lesions (= ERILs) or silent neurologic ischemic lesions (= SNILs) after acute stroke or transitoric ischemic attack (TIA) based on atherothrombosis (LAA-stroke) on standard therapy during 30 days (day 7 and day 30 after acute event) via DW-MRI (diffusion-weighted magnetic resonance imaging).
We want to investigate if diffusion-weighted imaging of silent brain infarcts occuring during standard therapy is a suitable surrogate outcome measure for interventional studies
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •LAA stroke or TIA
- •ERILs or SNILs detected in initialDW-MRI
- •signed informed consent
排除标准
- •planned surgical intervention
- •iv Thrombolysis
- •atrial fibrillation
- •contra indications against DW-MRI
结局指标
主要结局
1. How many ERILs occur in caucasian patients with LAA stroke during 7 days on standard treatment?
时间窗: 7 days after acute stroke
DW-MRI to detect lesions
次要结局
- 2. How many SNILs occur between 7 and 30 days after acute ischemic event on standard treatment and how many of during acute event diagnosed lesions (ERILs) are (still) detectable after 30 days?(30 days after acute stroke)
研究者
Christa Firbas MD
MD
Medical University of Vienna