The Utility of Serum Tryptase in the Diagnosis of Shrimp- Induced Anaphylaxis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 39
- 试验地点
- 2
- 主要终点
- Change of Serum tryptases
研究概览
简要总结
The purpose of this study was to investigate the utility of serum tryptase for the confirmation of shrimp-induced anaphylaxis.
详细描述
The diagnosis of anaphylaxis is based primarily on the clinical history. In some circumstances, inability to confirm the clinical diagnosis such as present with unusual manifestation, or when skin signs are absent likely contributes to underrecognition and undertreatment of the disease.
Currently, products of mast cell activation (histamine and total tryptase) can be measure in clinical laboratories as markers of acute anaphylaxis events, however these tests have clinically relevant limitations.
Therefore, development of laboratory tests with improved sensitivity and specificity that will support the clinical diagnosis of anaphylaxis are needed.
In addition, shrimp is the major cause of seafood anaphylaxis among Thai children.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 5 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •a history of shrimp allergy
排除标准
- •severe anaphylactic reaction from seafood
- •pregnancy
- •underlying diseases such as cardiovascular, hepatobiliary, and renal diseases
- •on systemic corticosteroid or β-blocking agents
结局指标
主要结局
Change of Serum tryptases
时间窗: baseline and 60 minutes after the onset of symptoms
次要结局
未报告次要终点