Determinants of Formate Concentrations

Completed

• Conditions: Healthy

• Registration Number: NCT03305900
• Lead Sponsor: Memorial University of Newfoundland

Brief Summary

Formate is an important metabolite, serving as a donor of one-carbon groups to the intracellular tetrahydrofolate pool. However, little is known of its circulating concentrations or of their determinants. This study seeks to define formate levels and their determinants in a young, healthy population.

Serum formate will be measured in 1701 subjects from the Trinity Student Study. The subjects, males and females, aged 18 to 28 years, were enrolled at Trinity College, Dublin. Formate levels will be compared with other one-carbon metabolites, vitamin status, potential formate precursors, genetic polymorphisms, and lifestyle factors.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-12-01
• Primary Completion: 2013-11-26
• Study Completion: 2013-11-26
• Study First Submitted: 2017-09-28
• Status Verified: 2017-10
• Study First Submitted QC: 2017-10-04
• Last Update Submitted: 2017-10-04
• Study First Posted: 2017-10-10
• Last Update Posted: 2017-10-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1701

Inclusion Criteria

• Trinity College Dublin students with Irish grandparents

Exclusion Criteria

• None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Formate concentrations	Single baseline measurement; cross sectional, observational study	Formate concentrations in study population