Preventive antibacterial short-term therapy in patients with acute ischemic infarction in the territory of the middle cerebral artery (MCA)
- Conditions
- StrokeCirculatory System
- Registration Number
- ISRCTN74386719
- Lead Sponsor
- Charité - University Medicine Berlin (Charité - Universitätsmedizin Berlin) (Germany)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 80
The double blind, randomised and controlled study will be carried out on two groups of about 40 patients each. Since patients with large infarctions in the territory of the middle cerebral artery and a subsequent severe neurological deficit (National Institutes of Health-Stroke-Scale [NIHSS] greater than 11) have the highest risk of pneumonia, we include only this subpopulation of stroke patients in our study.
1. Severe ischemic strokes in MCA territory (area greater than 50% in cerebral computed tomography [CCT], NIHSS greater than 11)
2. Within 36 hours after stroke onset
3. Older than 18 years
4. No infection
5. No intracerebral bleeding
1. Immunosupressive therapy
2. Pregnancy
3. Antibacterial therapy within the last 24 hours before inclusion
4. Contraindication for moxifloxacin
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ot provided at time of registration
- Secondary Outcome Measures
Name Time Method ot provided at time of registration