GastroIntestinal Cancer in Children and Adolescents (GICCA): a SEER Population-based Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 2,500
- 试验地点
- 2
- 主要终点
- Overall survival
研究概览
简要总结
The goal of this observational population-based cohort study is to investigate the clinical characteristics and outcomes of children and adolescents with primary gastrointestinal malignancies registered in the publicly available Surveillance, Epidemiology, and End Results (SEER) 17 database during 2000-2019.
详细描述
The investigators aim to describe the patient and tumor characteristics, treatments, and outcomes of children and adolescents diagnosed with primary gastrointestinal malignancies, and to analyze these data for trends over time. In addition, the investigators want to explore independent prognostic factors for overall survival. Finally, the investigators want to describe subsequent primary malignancies diagnosed among patients from the study cohort, as well as to calculate their risk of developing a second primary cancer relative to the general population. Data on children (aged 0-17 years at diagnosis) and young people aged 18-24 years at diagnosis are analyzed separately. Special focus is laid on patients with primary carcinomas of the gastrointestinal tract; particularly colorectal carcinoma.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 0 Years 至 24 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age at primary gastrointestinal cancer diagnosis <25 years
- •Diagnosis of a primary gastrointestinal malignancy as an individual's first primary malignancy
排除标准
- 未提供
结局指标
主要结局
Overall survival
时间窗: 2000-2019
Defined as the time between the date of diagnosis and the date of death from any cause (event) or date of last follow-up.
次要结局
- Standardized incidence of second primary malignancies(2000-2019)
研究者
Paul G. Kemps, MD
Researcher
Leiden University Medical Center