The Predictive and Diagnostic Value of Cystatin C and High Sensitive Troponin

• Conditions: Chronic Kidney Diseases; Acute Coronary Syndrome
• Interventions: Procedure: percutaneous coronary intervention

• Registration Number: NCT05303441
• Lead Sponsor: Ankara Diskapi Training and Research Hospital

Brief Summary

Our study is planning to evaluate patients with chronic kidney disease who come to the emergency department with chest pain. Estimated GFR (cisGFR) with cystatin and estimated GFR (creaGFR) with creatinine will be calculated. Symptoms, ECG and troponin values of patients will be evaluated for diagnosis of acute coronary syndrome

Detailed Description

Our study is planning to evaluate patients with chronic kidney disease who come to the emergency department with chest pain. Estimated GFR (cisGFR) with cystatin and estimated GFR (creaGFR) with creatinine will be calculated. Symptoms, ECG and troponin values of patients will be evaluated for diagnosis of acute coronary syndrome and the final diagnosis of AMI will be adjudicated by 2 independent cardiologists.Serial troponin measurements and eGFR values will be proportioned. These values the will be evaluated and compared for patients with acute coronary syndrome(culprit lesion on conventional coronary angiography) and non-ACS ones . With these data we aim to facilitate the diagnosis of acute coronary syndrome,increase the specificity and sensitivity of cardiac troponins for the diagnosis of acute coronary syndrome of patients with chronic kidney disease, increase the utility of high sensitive troponins for patients with chronic kidney disease. Again, with these data, it is aimed to reduce the number of false negative and false positive diagnosis of acute coronary syndrome .

Study Timeline

• Status Verified: 2022-03
• Study Start: 2022-03-07
• Study First Submitted: 2022-03-09
• Study First Submitted QC: 2022-03-29
• Last Update Submitted: 2022-03-29
• Study First Posted: 2022-03-31
• Last Update Posted: 2022-03-31
• Primary Completion: 2023-01-07
• Study Completion: 2023-02-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 172

Inclusion Criteria

1. Age over 18,
2. chronic kidney diease having chest pain or equivalent of chest pain (dyspnea, diaphoresis, syncope, nausea, vomiting) -

Exclusion Criteria

1. STEMI,
2. age less than 18,
3. missing data,
4. patients referred to or accepted from another medical facility

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
patients with acute coronary syndrome	percutaneous coronary intervention	patients with chronic kidney disease having chest pain with ecg, symptom or cardiac troponin levels compatible with ACS

Primary Outcome Measures

Name	Time	Method
exclusion of acs	time passed during emergency department visit until discharge avarage of 3-6 hours	exclusion of ACS according to current guidelines
anticipated ACS	time passed until PCI (percutaneous coronary intervention) (pre-intervention) or admission to hospital	The role of cystatin C in diagnosis acute coronary syndrome when used with troponin in patients with chronic renal failure.

Trial Locations

Locations (1)

Diskapi Research and Training Hospital; 🇹🇷 Ankara, Turkey