Study of Seroprevalence of Anti-SARS-CoV2 Among Children of Hospital Workers in AP-HP

Not Applicable

Completed

• Conditions: SARS-CoV2

• Registration Number: NCT04442087
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

The purpose of this study is to define seroprevalence of anti-SARS-CoV2 among children of Hospital Workers in APHP, particularly exposed population, according to parents' SARS-CoV2 serological status.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-06-08
• Study Start: 2020-06-19
• Study First Submitted QC: 2020-06-19
• Study First Posted: 2020-06-22
• Primary Completion: 2021-04-30
• Study Completion: 2021-04-30
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-19
• Last Update Posted: 2021-11-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 563

Inclusion Criteria

Hospital workers :

1. Individuals aged over 18, having a professional activity at the APHP (employees, interns, volunteers)
2. Affiliated to a social security regimen
3. Have at least one child under the age of 18 living in the same house.
4. have signed consent

Child (ren), spouse and other member (s) residing at household:

Child (ren), spouse and any other member residing in the household of a professional of the Paris Center Hospitals meeting the inclusion criteria above.

Exclusion Criteria

Refuse to participate in research

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Seroprevalence of antibodies anti- SARS Cov2 in blood sample of children of Hospital workers	at inclusion	Percentage of children with seropositive in blood sample according to parents' SARS Cov2 serological status
Seroprevalence of antibodies anti- SARS Cov2 in saliva sample of children of Hospital workers	at inclusion	Percentage of children with seropositive according in saliva sample to parents' SARS Cov2 serological status

Secondary Outcome Measures

Name	Time	Method
Number of severely symptomatic Children with a positive serology	At inclusion
Number of spouses of hospital workers with a positive serology	At inclusion
Number of Asymptomatic spouses of hospital workers with a positive serology	At inclusion
Number of Asymptomatic Children with a positive seroloy	At inclusion
Prevalence of different clinical symptoms in children with a positive serology	At inclusion
Serological result of each member of the family	At inclusion
Number of severely symptomatic spouses of hospital workers with a positive serology	At inclusion
Comparison of Serological result obtained in blood and saliva samples	At inclusion
Risk factors based on a questionnaire for children and adults	At inclusion	the following factors will be of particular importance: characteristics and composition of the family home, barrier measures, medical history and comorbidities.

Trial Locations

Locations (1)

Centre d'investigation clinique (CIC) Necker Cochin in Necker Children's Hospital; 🇫🇷 Paris, France