Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects
- Registration Number
- NCT05232916
- Lead Sponsor
- Greenwich LifeSciences, Inc.
- Brief Summary
This is a prospective, randomized, double-blinded, placebo-controlled, multi-center, Phase 3 study of GLSI-100 immunotherapy in HLA-A\*02 positive and HER2/neu positive subjects who are at high risk for disease recurrence and have completed both neoadjuvant and postoperative adjuvant standard of care therapy. Treatment consists of 6 intradermal injections, Primary Immunization Series (PIS), over the first 6 months of treatment and 5 booster intradermal injections spaced 6 months apart. A third open-label arm will explore GLSI-100 immunotherapy in non-HLA-A\*02 positive and HER2/neu positive subjects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 598
- HLA-A*02-positive, unless being enrolled in the third non-HLA-A*02 arm
- Histologically confirmed diagnosis of HER2/neu positive primary breast cancer
- Completion of both neoadjuvant and adjuvant trastuzumab-based standard of care breast cancer therapy
- Stage I, II, or III at presentation with pathologic evidence of residual invasive carcinoma in the breast or axillary lymph nodes (residual disease) at surgery following completion of neoadjuvant therapy -OR- Stage III at presentation with pathologic complete response (pCR) at surgery following completion of neoadjuvant therapy
- The subject can begin study therapy within one year of completion of adjuvant trastuzumab-based therapy and any other standard therapies, but, study therapy can be administered concurrently with endocrine therapy.
- No clinical evidence of residual or persistent breast cancer per treating physician assessment
- ECOG 0-2
- Adequate organ function
- Negative pregnancy test or evidence of post-menopausal status
- If of childbearing potential, willing to use a form of highly effective contraception
- Stage IV cancer or metastatic breast cancer at any time
- Inflammatory breast cancer
- Receiving other investigational agents
- Receiving chemotherapy
- Requiring long-term systemic treatment with corticosteroids or other immunosuppressive therapy
- History of immunodeficiency or active autoimmune disease
- A history of serious allergic reactions, including anaphylaxis, to human granulocyte-macrophage colony-stimulating factors such as sargramostim, yeast-derived products, or any component of the investigational product
- Other malignancies except adequately treated in situ carcinoma of the cervix or basal cell or squamous cell carcinoma of the skin
- Active infection
- Known HIV infection with a detectable viral load within 6 months of the anticipated start of treatment. Note: Subjects on effective antiretroviral therapy with an undetectable viral load within 6 months of the anticipated start of treatment are eligible for this trial.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 0.9% Normal Saline Placebo 0.9% normal saline in HLA-A\*02 positive and HER2/neu positive subjects administered intradermally every month for first 6 months then every 6 months for next 2.5 years (11 intradermal injections over 3 years) GLSI-100 GLSI-100 GLSI-100 immunotherapy in HLA-A\*02 positive and HER2/neu positive subjects administered intradermally every month for first 6 months then every 6 months for next 2.5 years (11 intradermal injections over 3 years) GLSI-100, Open-label GLSI-100 Open-label arm: GLSI-100 immunotherapy in non-HLA-A\*02 positive and HER2/neu positive subjects administered intradermally every month for first 6 months then every 6 months for next 2.5 years (11 intradermal injections over 3 years)
- Primary Outcome Measures
Name Time Method Invasive Breast Cancer-free Survival (IBCFS) Median 4 years of follow-up (interim analysis planned) IBCFS is defined as the time from the first dose of study medication until the date of ipsilateral invasive breast cancer recurrence, ipsilateral local-regional invasive breast cancer recurrence, distant recurrence, contralateral invasive breast cancer, or any cause mortality.
- Secondary Outcome Measures
Name Time Method Invasive Disease-free Survival (IDFS) Median 4 years of follow-up (interim analysis planned) IDFS is defined as the time from the first dose of study medication until the date of ipsilateral invasive breast cancer recurrence, ipsilateral local-regional invasive breast cancer recurrence, distant recurrence, contralateral invasive breast cancer, second primary non-breast invasive cancer, or any cause mortality.
Distant Disease-free Survival (DDFS) Median 4 years of follow-up (interim analysis planned) DDFS will be defined as the time from the first dose of study medication to the time of distant disease recurrence or death.
Overall Survival Median 4 years of follow-up (interim analysis planned) Overall survival will be defined as the time from the first dose of study medication until death from any cause.
Quality of Life Questionnaire Core 30 (QLQ-C30) Baseline and 36 months European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30)
Quality of Life FACT-GP5 Baseline and 36 months FACT-GP5 to assess global side effect impact
Trial Locations
- Locations (304)
Arizona Oncology Associates - Tucson
🇺🇸Tucson, Arizona, United States
Providence St. Jude Medical Center - Virginia K. Crosson Cancer Center
🇺🇸Fullerton, California, United States
University of California San Diego - Moores Cancer Center
🇺🇸La Jolla, California, United States
University of Southern California - Norris Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States
Stanford Medicine Cancer Center - Stanford Women's Cancer Center
🇺🇸Palo Alto, California, United States
University of California San Francisco - Helen Diller Family Comprehensive Cancer Center
🇺🇸San Francisco, California, United States
University of California Los Angeles - Hematology / Oncology Parkside
🇺🇸Santa Monica, California, United States
PIH Health Hospital - Whittier Hospital
🇺🇸Whittier, California, United States
Rocky Mountain Cancer Centers
🇺🇸Denver, Colorado, United States
Yale Cancer Center - Smilow Cancer Hospital
🇺🇸New Haven, Connecticut, United States
Johns Hopkins Medicine - Kimmel Cancer Center-Sibley Memorial Hospital
🇺🇸Washington, District of Columbia, United States
University of Miami - Sylvester Comprehensive Cancer Center
🇺🇸Miami, Florida, United States
Moffitt Cancer Center
🇺🇸Tampa, Florida, United States
Northwestern University - Northwestern Memorial Hospital
🇺🇸Chicago, Illinois, United States
Maryland Oncology Hematology
🇺🇸Annapolis, Maryland, United States
Massachusetts General Hospital Cancer Center
🇺🇸Boston, Massachusetts, United States
Minnesota Oncology - Maple Grove Clinic
🇺🇸Maple Grove, Minnesota, United States
Siteman Cancer Center - Washington University Medical Campus
🇺🇸Saint Louis, Missouri, United States
Nebraska Cancer Specialists
🇺🇸Omaha, Nebraska, United States
Nebraska Medicine - University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Comprehensive Cancer Centers of Nevada
🇺🇸Henderson, Nevada, United States
Cooper University Health Care
🇺🇸Camden, New Jersey, United States
New York Oncology Hematology
🇺🇸Albany, New York, United States
Columbia University Medical Center
🇺🇸New York, New York, United States
Stony Brook University Cancer Center
🇺🇸Stony Brook, New York, United States
Oncology Hematology Care
🇺🇸Cincinnati, Ohio, United States
Compass Oncology - Northwest Cancer Specialists
🇺🇸Tigard, Oregon, United States
Redeemer Health - Holy Redeemer Hospital
🇺🇸Meadowbrook, Pennsylvania, United States
Sidney Kimmel Comprehensive Cancer Center - Thomas Jefferson University Hospital
🇺🇸Philadelphia, Pennsylvania, United States
Texas Oncology - Austin
🇺🇸Austin, Texas, United States
Texas Oncology - Dallas Presbyterian Hospital
🇺🇸Dallas, Texas, United States
Texas Oncology - Baylor Charles A. Sammons Cancer Center
🇺🇸Dallas, Texas, United States
The University of Texas Southwestern Medical Center
🇺🇸Dallas, Texas, United States
Baylor College of Medicine - Dan L. Duncan Comprehensive Cancer Center
🇺🇸Houston, Texas, United States
The University of Texas Health Sciences Center at San Antonio - Mays Cancer Center
🇺🇸San Antonio, Texas, United States
Texas Oncology - San Antonio
🇺🇸San Antonio, Texas, United States
Texas Oncology - Gulf Coast
🇺🇸Sugar Land, Texas, United States
Texas Oncology - Tyler
🇺🇸Tyler, Texas, United States
University of Utah - Huntsman Cancer Institute
🇺🇸Salt Lake City, Utah, United States
Virginia Cancer Specialists
🇺🇸Fairfax, Virginia, United States
Sainte-Catherine - Institut du Cancer Avignon-Provence (ICAP)
🇫🇷Avignon, France
Centre Hospitalier Simone Veil de Beauvais
🇫🇷Beauvais, France
Centre François Baclesse (CLCC)
🇫🇷Caen, France
Centre Léon Bérard
🇫🇷Lyon, France
Centre Antoine Lacassagne
🇫🇷Nice, France
Centre Hospitalier Privé Sainte-Marie Osny
🇫🇷Osny, France
Institut Curie
🇫🇷Saint-Cloud, France
Hôpital NOVO (Nord-Ouest Val-d'Oise)
🇫🇷Pontoise, France
Centre Hospitalier Intercommunal de Cornouaille Quimper Concarneau (CHIC)
🇫🇷Quimper, France
Institut Godinot (CLCC)
🇫🇷Reims, France
Centre Hospitalier Privé Saint-Grégoire
🇫🇷Saint-Grégoire, France
Centre Hospitalier Universitaire de Saint-Étienne
🇫🇷Saint-Étienne, France
Institut de cancérologie Strasbourg Europe
🇫🇷Strasbourg, France
Hôpital privé Drôme Ardèche
🇫🇷Valence, France
Hôpital Robert Schuman
🇫🇷Vantoux, France
Institut Gustave Roussy
🇫🇷Villejuif, France
Hämatololgisch Onkologische Praxis Heinrich Bangerter Augsburg
🇩🇪Augsburg, Germany
Klinikum Bayreuth GmbH
🇩🇪Bayreuth, Germany
DBZ Onkologie GmbH
🇩🇪Berlin, Germany
HELIOS Klinikum Berlin-Buch
🇩🇪Berlin, Germany
Marienhospital Bottrop gGmbH
🇩🇪Bottrop, Germany
Evangelisches Diakonie-Krankenhaus Bremen
🇩🇪Bremen, Germany
Klinikum Chemnitz gGmbH
🇩🇪Chemnitz, Germany
Städtisches Klinikum Dessau
🇩🇪Dessau, Germany
St.-Johannes Hospital Dortmund
🇩🇪Dortmund, Germany
Universitätsklinikum Carl Gustav Carus
🇩🇪Dresden, Germany
Zentrum für Gynäkologische Onkologie Düsseldorf
🇩🇪Düsseldorf, Germany
Studienzentrale für das MVZ Eggenfelden e.K.
🇩🇪Eggenfelden, Germany
Kliniken Essen-Mitte
🇩🇪Essen, Germany
Klinikum Frankfurt Höchst GmbH
🇩🇪Frankfurt, Germany
Praxis für Interdisziplinäre Onkologie & Hämatologie
🇩🇪Freiburg, Germany
Helios Klinikum Gifhorn GmbH - Brustzentrum
🇩🇪Gifhorn, Germany
Universitätsmedizin Göttingen
🇩🇪Göttingen, Germany
Krankenhaus St. Elisabeth und St. Barbara Halle (Saale) GmbH
🇩🇪Halle, Germany
Gynäkologische Praxisklinik Hamburg-Harburg
🇩🇪Hamburg-Harburg, Germany
Mammazentrum Hamburg
🇩🇪Hamburg, Germany
Universitätsklinikum Heidelberg
🇩🇪Heidelberg, Germany
Elisabeth Krankenhaus Kassel
🇩🇪Kassel, Germany
MVZ GynKrefeld GmbH am Helios Klinikum Krefeld
🇩🇪Krefeld, Germany
Gemeinschaftspraxis für Hämatologie und Onkologie Langen
🇩🇪Langen, Germany
Studienzentrum UnterEms Leer
🇩🇪Leer, Germany
RKH Klinikum Ludwigsburg
🇩🇪Ludwigsburg, Germany
Universitätsmedizin Mainz
🇩🇪Mainz, Germany
Universitätsfrauenklinik Mannheim
🇩🇪Mannheim, Germany
München Klinik gGmbH
🇩🇪Munich, Germany
TUM München
🇩🇪Munich, Germany
Klinikum Südstadt, Universitätsfrauenklinik
🇩🇪Rostock, Germany
GPR Klinikum Rüsselsheim
🇩🇪Rüsselsheim, Germany
Diakonissen-Stiftungs-Krankenhaus Speyer
🇩🇪Speyer, Germany
Klinikum Mutterhaus der Borromäerinnen gGmbH
🇩🇪Trier, Germany
Universitätsklinikum Ulm AöR
🇩🇪Ulm, Germany
Marienhospital Witten
🇩🇪Witten, Germany
Klinikum Worms - Frauenklinik
🇩🇪Worms, Germany
Helios Universitätsklinikum Wuppertal
🇩🇪Wuppertal, Germany
Azienda Ospedaliero Universitaria di Bologna Policlinico di Sant'Orsola IRCCS (Istituto Di Ricerca E Di Cura A Carattere Scientifico)
🇮🇹Bologna, Italy
Ospedale Policlinico San Martino IRCCS (Istituto Di Ricerca E Di Cura A Carattere Scientifico)
🇮🇹Genova, Italy
Humanitas Research Hospital
🇮🇹Milan, Italy
Azienda Ospedaliera Universitaria Federico II Di Napoli
🇮🇹Naples, Italy
Istituto Nazionale Tumori Fondazione Pascale IRCCS (Istituto Di Ricerca E Di Cura A Carattere Scientifico)
🇮🇹Naples, Italy
Azienda Ospedaliero Universitaria Maggiore della Carità di Novara
🇮🇹Novara, Italy
Istituto Oncologico Veneto
🇮🇹Padova, Italy
Istituti Clinici Scientifici Maugeri Spa Società Benefit IRCCS (Istituto Di Ricerca E Di Cura A Carattere Scientifico)
🇮🇹Pavia, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS (Istituto Di Ricerca E Di Cura A Carattere Scientifico)
🇮🇹Rome, Italy
Przychodnia Lekarska KOMED Roman Karaszewski
🇵🇱Konin, Poland
Samodzielny Publiczny Zakład Opieki Zdrowotnej (ZOZ) Szpital Uniwersytecki w Krakowie
🇵🇱Kraków, Poland
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie
🇵🇱Kraków, Poland
Samodzielny Publiczny Zakład Opieki Zdrowotnej (SPOZOZ) Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w Opolu
🇵🇱Opole, Poland
Uniwersytecki Szpital Kliniczny w Poznaniu
🇵🇱Poznań, Poland
Centrum Medyczne MrukMed
🇵🇱Rzeszów, Poland
Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka w Słupsku
🇵🇱Słupsk, Poland
Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie
🇵🇱Warsaw, Poland
Wojskowy Instytut Medyczny, Państwowy Instytut Badawczy
🇵🇱Warsaw, Poland
Complejo Hospitalario Universitario de Albacete
🇪🇸Albacete, Spain
Hospital General Universitario Dr. Balmis
🇪🇸Alicante, Spain
Hospital Universitario de Badajoz
🇪🇸Badajoz, Spain
Hospital Clínic De Barcelona
🇪🇸Barcelona, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Hospital San Pedro de Alcántara
🇪🇸Cáceres, Spain
Hospital Universitario Reina Sofía
🇪🇸Córdoba, Spain
Hospital Clínico Universitario Virgen de la Arrixaca
🇪🇸El Palmar, Spain
Hospital Universitario de Fuenlabrada
🇪🇸Fuenlabrada, Spain
Hospital Galdakao-Usansolo
🇪🇸Galdakao, Spain
Hospital Universitario Clínico San Cecilio
🇪🇸Granada, Spain
Hospital Universitario de Jaén
🇪🇸Jaén, Spain
Hospital Universitario de Jerez de la Frontera
🇪🇸Jerez De La Frontera, Spain
Hospital Universitario de Canarias
🇪🇸La Laguna, Spain
Hospital Universitari Arnau de Vilanova (Lleida)
🇪🇸Lleida, Spain
Hospital General Universitario Gregorio Marañón
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital Universitario Fundación Jiménez Díaz
🇪🇸Madrid, Spain
Hospital Universitario HM Sanchinarro
🇪🇸Madrid, Spain
Hospital Universitario Infanta Leonor
🇪🇸Madrid, Spain
Hospital Universitario Puerta de Hierro Majadahonda
🇪🇸Majadahonda, Spain
Althaia, Xarxa Assistencial Universitària de Manresa
🇪🇸Manresa, Spain
Hospital General Universitario Morales Meseguer
🇪🇸Murcia, Spain
Hospital Clínico Universitario Virgen de la Victoria
🇪🇸Málaga, Spain
Hospital Regional Universitario de Malaga
🇪🇸Málaga, Spain
Hospital Universitari Son Espases
🇪🇸Palma De Mallorca, Spain
Hospital Universitario San Juan de Alicante
🇪🇸San Juan De Alicante, Spain
Hospital Universitario Donostia
🇪🇸San Sebastián, Spain
Hospital Universitari General de Catalunya - Grupo Quirónsalud
🇪🇸Sant Cugat Del Vallès, Spain
Hospital Universitario Nuestra Señora de Candelaria
🇪🇸Santa Cruz De Tenerife, Spain
Hospital Clínico Universitario de Santiago
🇪🇸Santiago de Compostela, Spain
Hospital Universitario Virgen del Rocío
🇪🇸Sevilla, Spain
Hospital Universitario Virgen Macarena
🇪🇸Sevilla, Spain
Hospital Universitario de Toledo
🇪🇸Toledo, Spain
Consorcio Hospital General Universitario de Valencia
🇪🇸Valencia, Spain
Fundación Instituto Valenciano de Oncología
🇪🇸Valencia, Spain
Hospital Clínico Universitario de Valencia
🇪🇸Valencia, Spain
Hospital Universitari Arnau de Vilanova (Valencia)
🇪🇸Valencia, Spain
Hospital Universitario Miguel Servet
🇪🇸Zaragoza, Spain
Clinique Pasteur-Lanroze
🇫🇷Brest, France
Marienhospital Bottrop gGmbH
🇩🇪Bottrop, Germany
Arizona Oncology Associates - Tucson
🇺🇸Tucson, Arizona, United States
Providence St. Jude Medical Center - Virginia K. Crosson Cancer Center
🇺🇸Fullerton, California, United States
University of California San Diego - Moores Cancer Center
🇺🇸La Jolla, California, United States
University of Southern California - Norris Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States
Stanford Medicine Cancer Center - Stanford Women's Cancer Center
🇺🇸Palo Alto, California, United States
University of California San Francisco - Helen Diller Family Comprehensive Cancer Center
🇺🇸San Francisco, California, United States
University of California Los Angeles - Hematology / Oncology Parkside
🇺🇸Santa Monica, California, United States
PIH Health Hospital - Whittier Hospital
🇺🇸Whittier, California, United States
Rocky Mountain Cancer Centers
🇺🇸Denver, Colorado, United States
Yale Cancer Center - Smilow Cancer Hospital
🇺🇸New Haven, Connecticut, United States
Johns Hopkins Medicine - Kimmel Cancer Center-Sibley Memorial Hospital
🇺🇸Washington, District of Columbia, United States
University of Miami - Sylvester Comprehensive Cancer Center
🇺🇸Miami, Florida, United States
Moffitt Cancer Center
🇺🇸Tampa, Florida, United States
Northwestern University - Northwestern Memorial Hospital
🇺🇸Chicago, Illinois, United States
Maryland Oncology Hematology
🇺🇸Annapolis, Maryland, United States
Massachusetts General Hospital Cancer Center
🇺🇸Boston, Massachusetts, United States
Minnesota Oncology - Maple Grove Clinic
🇺🇸Maple Grove, Minnesota, United States
Siteman Cancer Center - Washington University Medical Campus
🇺🇸Saint Louis, Missouri, United States
Nebraska Cancer Specialists
🇺🇸Omaha, Nebraska, United States
DBZ Onkologie GmbH
🇩🇪Berlin, Germany
Nebraska Medicine - University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Comprehensive Cancer Centers of Nevada
🇺🇸Henderson, Nevada, United States
Cooper University Health Care
🇺🇸Camden, New Jersey, United States
New York Oncology Hematology
🇺🇸Albany, New York, United States
Columbia University Medical Center
🇺🇸New York, New York, United States
Stony Brook University Cancer Center
🇺🇸Stony Brook, New York, United States
Oncology Hematology Care
🇺🇸Cincinnati, Ohio, United States
Compass Oncology - Northwest Cancer Specialists
🇺🇸Tigard, Oregon, United States
Redeemer Health - Holy Redeemer Hospital
🇺🇸Meadowbrook, Pennsylvania, United States
Sidney Kimmel Comprehensive Cancer Center - Thomas Jefferson University Hospital
🇺🇸Philadelphia, Pennsylvania, United States
Texas Oncology - Austin
🇺🇸Austin, Texas, United States
Texas Oncology - Dallas Presbyterian Hospital
🇺🇸Dallas, Texas, United States
Texas Oncology - Baylor Charles A. Sammons Cancer Center
🇺🇸Dallas, Texas, United States
The University of Texas Southwestern Medical Center
🇺🇸Dallas, Texas, United States
Baylor College of Medicine - Dan L. Duncan Comprehensive Cancer Center
🇺🇸Houston, Texas, United States
HELIOS Klinikum Berlin-Buch
🇩🇪Berlin, Germany
The University of Texas Health Sciences Center at San Antonio - Mays Cancer Center
🇺🇸San Antonio, Texas, United States
Texas Oncology - San Antonio
🇺🇸San Antonio, Texas, United States
Texas Oncology - Gulf Coast
🇺🇸Sugar Land, Texas, United States
Texas Oncology - Tyler
🇺🇸Tyler, Texas, United States
University of Utah - Huntsman Cancer Institute
🇺🇸Salt Lake City, Utah, United States
Virginia Cancer Specialists
🇺🇸Fairfax, Virginia, United States
Sainte-Catherine - Institut du Cancer Avignon-Provence (ICAP)
🇫🇷Avignon, France
Centre Hospitalier Simone Veil de Beauvais
🇫🇷Beauvais, France
Clinique Pasteur-Lanroze
🇫🇷Brest, France
Centre François Baclesse (CLCC)
🇫🇷Caen, France
Centre Léon Bérard
🇫🇷Lyon, France
Centre Antoine Lacassagne
🇫🇷Nice, France
Centre Hospitalier Privé Sainte-Marie Osny
🇫🇷Osny, France
Institut Curie
🇫🇷Saint-Cloud, France
Hôpital NOVO (Nord-Ouest Val-d'Oise)
🇫🇷Pontoise, France
Centre Hospitalier Intercommunal de Cornouaille Quimper Concarneau (CHIC)
🇫🇷Quimper, France
Institut Godinot (CLCC)
🇫🇷Reims, France
Centre Hospitalier Privé Saint-Grégoire
🇫🇷Saint-Grégoire, France
Centre Hospitalier Universitaire de Saint-Étienne
🇫🇷Saint-Étienne, France
Institut de cancérologie Strasbourg Europe
🇫🇷Strasbourg, France
Hôpital privé Drôme Ardèche
🇫🇷Valence, France
Hôpital Robert Schuman
🇫🇷Vantoux, France
Institut Gustave Roussy
🇫🇷Villejuif, France
Hämatololgisch Onkologische Praxis Heinrich Bangerter Augsburg
🇩🇪Augsburg, Germany
Klinikum Bayreuth GmbH
🇩🇪Bayreuth, Germany
Evangelisches Diakonie-Krankenhaus Bremen
🇩🇪Bremen, Germany
Klinikum Chemnitz gGmbH
🇩🇪Chemnitz, Germany
Städtisches Klinikum Dessau
🇩🇪Dessau, Germany
St.-Johannes Hospital Dortmund
🇩🇪Dortmund, Germany
Universitätsklinikum Carl Gustav Carus
🇩🇪Dresden, Germany
Zentrum für Gynäkologische Onkologie Düsseldorf
🇩🇪Düsseldorf, Germany
Studienzentrale für das MVZ Eggenfelden e.K.
🇩🇪Eggenfelden, Germany
Kliniken Essen-Mitte
🇩🇪Essen, Germany
Klinikum Frankfurt Höchst GmbH
🇩🇪Frankfurt, Germany
Praxis für Interdisziplinäre Onkologie & Hämatologie
🇩🇪Freiburg, Germany
Helios Klinikum Gifhorn GmbH - Brustzentrum
🇩🇪Gifhorn, Germany
Universitätsmedizin Göttingen
🇩🇪Göttingen, Germany
Krankenhaus St. Elisabeth und St. Barbara Halle (Saale) GmbH
🇩🇪Halle, Germany
Gynäkologische Praxisklinik Hamburg-Harburg
🇩🇪Hamburg-Harburg, Germany
Mammazentrum Hamburg
🇩🇪Hamburg, Germany
Universitätsklinikum Heidelberg
🇩🇪Heidelberg, Germany
Elisabeth Krankenhaus Kassel
🇩🇪Kassel, Germany
MVZ GynKrefeld GmbH am Helios Klinikum Krefeld
🇩🇪Krefeld, Germany
Gemeinschaftspraxis für Hämatologie und Onkologie Langen
🇩🇪Langen, Germany
Studienzentrum UnterEms Leer
🇩🇪Leer, Germany
RKH Klinikum Ludwigsburg
🇩🇪Ludwigsburg, Germany
Universitätsmedizin Mainz
🇩🇪Mainz, Germany
Universitätsfrauenklinik Mannheim
🇩🇪Mannheim, Germany
München Klinik gGmbH
🇩🇪Munich, Germany
TUM München
🇩🇪Munich, Germany
Klinikum Südstadt, Universitätsfrauenklinik
🇩🇪Rostock, Germany
GPR Klinikum Rüsselsheim
🇩🇪Rüsselsheim, Germany
Diakonissen-Stiftungs-Krankenhaus Speyer
🇩🇪Speyer, Germany
Klinikum Mutterhaus der Borromäerinnen gGmbH
🇩🇪Trier, Germany
Universitätsklinikum Ulm AöR
🇩🇪Ulm, Germany
Marienhospital Witten
🇩🇪Witten, Germany
Klinikum Worms - Frauenklinik
🇩🇪Worms, Germany
Helios Universitätsklinikum Wuppertal
🇩🇪Wuppertal, Germany
Azienda Ospedaliero Universitaria di Bologna Policlinico di Sant'Orsola IRCCS (Istituto Di Ricerca E Di Cura A Carattere Scientifico)
🇮🇹Bologna, Italy
Ospedale Policlinico San Martino IRCCS (Istituto Di Ricerca E Di Cura A Carattere Scientifico)
🇮🇹Genova, Italy
Humanitas Research Hospital
🇮🇹Milan, Italy
Azienda Ospedaliera Universitaria Federico II Di Napoli
🇮🇹Naples, Italy
Istituto Nazionale Tumori Fondazione Pascale IRCCS (Istituto Di Ricerca E Di Cura A Carattere Scientifico)
🇮🇹Naples, Italy
Azienda Ospedaliero Universitaria Maggiore della Carità di Novara
🇮🇹Novara, Italy
Istituto Oncologico Veneto
🇮🇹Padova, Italy
Istituti Clinici Scientifici Maugeri Spa Società Benefit IRCCS (Istituto Di Ricerca E Di Cura A Carattere Scientifico)
🇮🇹Pavia, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS (Istituto Di Ricerca E Di Cura A Carattere Scientifico)
🇮🇹Rome, Italy
Przychodnia Lekarska KOMED Roman Karaszewski
🇵🇱Konin, Poland
Samodzielny Publiczny Zakład Opieki Zdrowotnej (ZOZ) Szpital Uniwersytecki w Krakowie
🇵🇱Kraków, Poland
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie
🇵🇱Kraków, Poland
Samodzielny Publiczny Zakład Opieki Zdrowotnej (SPOZOZ) Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w Opolu
🇵🇱Opole, Poland
Uniwersytecki Szpital Kliniczny w Poznaniu
🇵🇱Poznań, Poland
Centrum Medyczne MrukMed
🇵🇱Rzeszów, Poland
Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka w Słupsku
🇵🇱Słupsk, Poland
Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie
🇵🇱Warsaw, Poland
Wojskowy Instytut Medyczny, Państwowy Instytut Badawczy
🇵🇱Warsaw, Poland
Complejo Hospitalario Universitario de Albacete
🇪🇸Albacete, Spain
Hospital General Universitario Dr. Balmis
🇪🇸Alicante, Spain
Hospital Universitario de Badajoz
🇪🇸Badajoz, Spain
Hospital Clínic De Barcelona
🇪🇸Barcelona, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Hospital San Pedro de Alcántara
🇪🇸Cáceres, Spain
Hospital Universitario Reina Sofía
🇪🇸Córdoba, Spain
Hospital Clínico Universitario Virgen de la Arrixaca
🇪🇸El Palmar, Spain
Hospital Universitario de Fuenlabrada
🇪🇸Fuenlabrada, Spain
Hospital Galdakao-Usansolo
🇪🇸Galdakao, Spain
Hospital Universitario Clínico San Cecilio
🇪🇸Granada, Spain
Hospital Universitario de Jaén
🇪🇸Jaén, Spain
Hospital Universitario de Jerez de la Frontera
🇪🇸Jerez De La Frontera, Spain
Hospital Universitario de Canarias
🇪🇸La Laguna, Spain
Hospital Universitari Arnau de Vilanova (Lleida)
🇪🇸Lleida, Spain
Hospital General Universitario Gregorio Marañón
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital Universitario Fundación Jiménez Díaz
🇪🇸Madrid, Spain
Hospital Universitario HM Sanchinarro
🇪🇸Madrid, Spain
Hospital Universitario Infanta Leonor
🇪🇸Madrid, Spain
Hospital Universitario Puerta de Hierro Majadahonda
🇪🇸Majadahonda, Spain
Althaia, Xarxa Assistencial Universitària de Manresa
🇪🇸Manresa, Spain
Hospital General Universitario Morales Meseguer
🇪🇸Murcia, Spain
Hospital Clínico Universitario Virgen de la Victoria
🇪🇸Málaga, Spain
Hospital Regional Universitario de Malaga
🇪🇸Málaga, Spain
Hospital Universitari Son Espases
🇪🇸Palma De Mallorca, Spain
Hospital Universitario San Juan de Alicante
🇪🇸San Juan De Alicante, Spain
Hospital Universitario Donostia
🇪🇸San Sebastián, Spain
Hospital Universitari General de Catalunya - Grupo Quirónsalud
🇪🇸Sant Cugat Del Vallès, Spain
Hospital Universitario Nuestra Señora de Candelaria
🇪🇸Santa Cruz De Tenerife, Spain
Hospital Clínico Universitario de Santiago
🇪🇸Santiago de Compostela, Spain
Hospital Universitario Virgen del Rocío
🇪🇸Sevilla, Spain
Hospital Universitario Virgen Macarena
🇪🇸Sevilla, Spain
Hospital Universitario de Toledo
🇪🇸Toledo, Spain
Consorcio Hospital General Universitario de Valencia
🇪🇸Valencia, Spain
Fundación Instituto Valenciano de Oncología
🇪🇸Valencia, Spain
Hospital Clínico Universitario de Valencia
🇪🇸Valencia, Spain
Hospital Universitari Arnau de Vilanova (Valencia)
🇪🇸Valencia, Spain
Hospital Universitario Miguel Servet
🇪🇸Zaragoza, Spain