Effect-site Concentration of Remifentanil for Blunting Hemodynamic Responses to Double-lumen Endobronchial Intubation

Not Applicable

• Conditions: Intubation, Intratracheal
• Interventions: Drug: Remifentanil

• Registration Number: NCT02001285
• Lead Sponsor: Jeju National University School of Medicine

Brief Summary

The purpose of this study is the comparison of the effect-site concentration of remifentanil for blunting hemodynamic responses to ordinary tracheal and double-lumen endobronchial intubation during propofol-remifentanil total intravenous anesthesia.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10
• Study First Submitted: 2013-10-28
• Status Verified: 2013-11
• Study First Submitted QC: 2013-11-27
• Last Update Submitted: 2013-11-27
• Study First Posted: 2013-12-04
• Last Update Posted: 2013-12-04
• Primary Completion: 2015-09
• Study Completion: 2015-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Adult patient who is needed intubation for general anesthesia

Exclusion Criteria

• patient who is anticipating difficult airway
• patient who takes any drug to influence this study
• cardiovascular disease, renal disease, liver disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Double lumen tube	Remifentanil	This arm contains patients who are needed endobronchial intubation with double lumen tube for general anesthesia. After propofol infusion of effect site concentration 4 μg/ml, remifentanil infusion will be started with effect site concentration of 3.5 ng/ml. According to change arterial blood pressure and heart rate from baseline value, next remifentanil concentration will be regulated using up-and-down method. Step size of dose is 0.5 ng/ml.
single lumen tube	Remifentanil	This arm contains patients who are needed endotracheal intubation with single lumen tube for general anesthesia. After propofol infusion of effect site concentration 4 μg/ml, remifentanil infusion will be started with effect site concentration of 3.5 ng/ml. According to change arterial blood pressure and heart rate from baseline value, next remifentanil concentration will be regulated using up-and-down method. Step size of dose is 0.5 ng/ml.

Primary Outcome Measures

Name	Time	Method
arterial blood pressure	Change from baseline in arterial blood pressure at intubation period	Arterial blood pressure will be recorded before anesthesia, after propofol infusion, after remifentanil infusion and after intubation during 3 min with 1 min interval.

Secondary Outcome Measures

Name	Time	Method
heart rate	Change from baseline in heart rate at intubation period	Heart rate will be recorded before anesthesia, after propofol infusion, after remifentanil infusion and after intubation during 3 min with 1 min interval.

Trial Locations

Locations (1)

Jeju National University Hospital; 🇰🇷 Jeju-si, Jeju Special Self-Governing Province, Korea, Republic of